SELECTED MISCELLEANEOUS PUBLICATIONS 2018
Peptide-based biogenic dental product may cure cavities Phys Org April 12, 2018 by Jackson Holtz, University of Washington
More information: Sami Dogan et al, Biomimetic Tooth Repair: Amelogenin-Derived Peptide Enables in Vitro Remineralization of Human Enamel, ACS Biomaterials Science & Engineering (2018). DOI: 10.1021/acsbiomaterials.7b00959
SELECTED MISCELLEANEOUS PUBLICATIONS 2017
Schizophrenia originates early in pregnancy, 'mini-brain' research suggests MedicalXpress November 20, 2017
Drug Discovery AI to Scour a Universe of Molecules for Wonder Drugs SingularityHub Nov 19, 2017
IL11 is a crucial determinant of cardiovascular fibrosis Nature 13 November 2017
U.S. man with rare disease is first to undergo gene editing in the body (for Hunter syndrome) CBS News November 15, 2017
A null mutation in SERPINE1 protects against biological aging in humans Sci. Adv. 2017;3: eaao1617 15 November 2017
Scientists find missing clue to how HIV hacks cells to propagate itself PhysOrg November 8, 2017
The meaning of intragenomic conflict Nature Ecology and Evolution 06 November 2017
Autism treatments may restore brain connections MedicalXpress November 2, 2017
Intercellular competition and the inevitability of multicellular aging PNAS October 6, 2017
It's mathematically impossible to beat aging, scientists say PhysOrg October 30, 2017
300 neurons traced in extensive brain wiring map MedicalXpress October 30, 2017
Important mechanism of epigenetic gene regulation identified MedicalXpress October 30, 2017
Transplanted hematopoietic stem cells reverse damage caused by neuro-muscular disorder MedicalXpress October 26, 2017
Complete structure of mitochondrial respiratory supercomplex decoded MedicalXpress September 22, 2017
More information: Runyu Guo et al. Architecture of Human Mitochondrial Respiratory Megacomplex I 2 III 2 IV 2, Cell (2017). DOI: 10.1016/j.cell.2017.07.050
Exercise can make cells healthier, promoting longer life, study finds MedicalXpress September 22, 2017
"A new study shows that exercise triggers a process called mitophagy, where the muscle disposes of damaged mitochondria, making the muscle and cells healthier."
More information: Rhianna C. Laker et al. Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy, Nature Communications (2017). DOI: 10.1038/s41467-017-00520-9
Sanofi and Regeneron Announce Positive Dupilumab Topline Results From Phase 3 Trial in Uncontrolled Persistent Asthma Sanofi Monday, September 11, 2017
- Investigational dupilumab reduced severe asthma attacks and improved lung function -
Human skin cells transformed directly into motor neurons MedicalXpress September 7, 2017
"Motor neurons drive muscle contractions, and their damage underlies devastating diseases such as amyotrophic lateral sclerosis and spinal muscular atrophy, both of which ultimately lead to paralysis and early death."
"In new research, scientists at Washington University School of Medicine in St. Louis have converted skin cells from healthy adults directly into motor neurons without going through a stem cell state."
More information: Abernathy DG, Kim WK, McCoy MJ, Lake AM, Ouwenga R, Lee SW, Xing X, Li D, Lee HJ, Heuckeroth RO, Dougherty JD, Wang T, Yoo AS. MicroRNAs induce a permissive chromatin environment that enables neuronal subtype-specific reprogramming of adult human fibroblasts. Cell Stem Cell. Sept. 7, 2017.
Researchers discover how human cells maintain the correct number of chromosomes Phys Org July 28, 2017
Cell engineering: How to hack the genome Nature 2017 547, 477–479
"OK, so you CRISPR'd a human embryo Well, I'll hack & build chromosomes" Eric Topol
"As the human body forms from cells dividing, we thought it was nicely programmed. But it's more like trial & error" Eric Topol
Cover stories: A method for revealing chromatin Science 28 Jul 2017
ChromEMT: Visualizing 3D chromatin structure and compaction in interphase and mitotic cells Science 28 Jul 2017 Vol. 357
"So cool to see chromatin in living cells for the 1st time" Eric Topol
Researchers studying century-old drug in potential new approach to autism MedicalXpress May 26, 2017
"In a small, randomized Phase I/II clinical trial (SAT1), researchers at University of California San Diego School of Medicine say a 100-year-old drug called suramin, originally developed to treat African sleeping sickness, was safely administered to children with autism spectrum disorder (ASD), who subsequently displayed measurable, but transient, improvement in core symptoms of autism."
Acute Myocardial Infarction NEJM 2017; 376:2053-2064
Lab-Grown Blood Stem Cells Produced at Last Scientific American May 18, 2017
"Two research teams cook up recipe to make long-sought cells in mice and people"
Regular chocolate consumption may be linked to lower risk of heart flutter MedicalXpress May 23, 2017
More information: Chocolate intake and risk of clinically apparent atrial fibrillation: the Danish Diet, Cancer, and Health Study, heart.bmj.com/lookup/doi/10.1136/heartjnl-2016-310357
Editorial: Chocolate and prevention of atrial fibrillation: what is bad for the pancreas might be good for the atria? heart.bmj.com/lookup/doi/10.1136/heartjnl-2016-311026
Toward point-of-care management of chronic respiratory conditions: Electrochemical sensing of nitrite content in exhaled breath condensate using reduced graphene oxide Microsystems & Nanoengineering 22 May 2017
"A portable breath electrochemical sensor that detects lung inflammation asthma" Eric Topol
Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms Nature Genetics 22 May 2017
"When there's 73 genomic loci for coronary artery disease (15 new), it's good-bye Manhattan plot" Eric Topol
Effect of Statin Treatment vs Usual Care on Primary Cardiovascular Prevention Among Older Adults The ALLHAT-LLT Randomized Clinical Trial JAMA Internal Medicine May 22, 2017
"Conclusions and Relevance No benefit was found when pravastatin was given for primary prevention to older adults with moderate hyperlipidemia and hypertension, and a nonsignificant direction toward increased all-cause mortality with pravastatin was observed among adults 75 years and older."
"Statins in the elderly—a report the statin aficionados won't like" Eric Topol
Dynamic chromatin technologies: from individual molecules to epigenomic regulation in cells Nature Reviews Genetics 22 May 2017
"Single cell and molecule tech is accelerating our understanding of epigenomics: a wonderful review" Eric Topol
"Metformin—the 1 drug for T2DM—works, at least in part, via the gut" Eric Topol
A bioprosthetic ovary created using 3D printed microporous scaffolds restores ovarian function in sterilized mice Nature Communications 16 May 2017
"Des ovaires obtenus par impression 3D ont donné naissance à une progéniture en pleine santé" iatranshumanisme
First In Vivo Human Genome Editing to Be Tested in New Clinical Trial TheScientist May 18, 2017
Sangamo Therapeutics will use zinc finger nucleases to introduce the gene for a missing clotting factor into the livers of men with hemophilia B.
"1st in vivo genome editing clinical trial to start, with ZFNs (not CRISPR)" Eric Topol
"Survival for sepsis is highly influenced by time to antibiotic treatment" Eric Topol
Effect of artificial pancreas systems on glycaemic control in patients with type 1 diabetes: a systematic review and meta-analysis of outpatient randomised controlled trials The Lancet Diabetes & Endocrinology 19 May 2017
"Artificial pancreas improves glucose control & reduces hypoglycemia. My meta-analysis" Alanna Weisman
Diagnosing Alzheimer’s Using Saliva Biomarkers GEN News highlights May 19, 2017
See Diagnostic Biomarkers of Alzheimer’s Disease as Identified in Saliva using 1H NMR-Based Metabolomics Journal of Alzheimer's Disease, vol. 58, no. 2, pp. 355-359, 2017
Computer-assisted diagnosis for skin cancer: have we been outsmarted? The Lancet 20 May 2017
"Dermatologists outsmarted by deep learning?" Eric Topol
New study helps solve a great mystery in the organization of our DNA Phys Org May 18, 2017
Haematopoietic stem and progenitor cells from human pluripotent stem cells Nature 17 May 2017 Conversion of adult endothelium to immunocompetent haematopoietic stem cells Nature 17 May 2017 Blood: Education for stem cells Nature 17 May 2017
"Making blood stem cells in a dish, an important step forward" Eric Topol
Researchers take an important step toward an HIV vaccine MedicalXpress May 17, 2017
More information: Huanbin Xu et al. Mucosal Vaccination with Heterologous Viral Vectored Vaccine Targeting Subdominant SIV Accessory Antigens Strongly Inhibits Early Viral Replication, EBioMedicine (2017). DOI: 10.1016/j.ebiom.2017.03.003
Study reveals how HIV virus destroys lung tissue MedicalXpress May 17, 2017
More information: Nancy P.Y. Chung et al. HIV Reprograms Human Airway Basal Stem/Progenitor Cells to Acquire a Tissue-Destructive Phenotype, Cell Reports (2017). DOI: 10.1016/j.celrep.2017.04.026
MIT neuroscientists have developed a new understanding of how memories form MIT News April 6, 2017
"Neuroscientists identify brain circuit necessary for memory formation - An MIT study of the neural circuits that underlie memory process reveals, for the first time, that memories are formed simultaneously in the hippocampus and the long-term storage location in the brain’s cortex. This image shows memory engram cells (green and red) which are crucial for permanent memory storage in the prefrontal cortex. New findings challenge standard model of memory consolidation."
New gene therapy for vision loss proven safe in humans MedicalXpress May 16, 2017
"In a small and preliminary clinical trial, Johns Hopkins researchers and their collaborators have shown that an experimental gene therapy that uses viruses to introduce a therapeutic gene into the eye is safe and that it may be effective in preserving the vision of people with wet age-related macular degeneration (AMD)."
More information: The Lancet (2017). www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)30979-0/fulltext
Metabolic Phenotypes of Response to Vaccination in Humans Cell Volume 169, Issue 5, p862–877.e17, 18 May 2017
"Everything's individualized, including how each person responds to a vaccine" Eric Topol
A subcellular map of the human proteome Science 11 May 2017
Abstract "Resolving the spatial distribution of the human proteome at a subcellular level greatly increases our understanding of human biology and disease. Here, we present a comprehensive image-based map of the subcellular protein distribution, the Cell Atlas, built by integrating transcriptomics and antibody-based immunofluorescence microscopy with validation by mass spectrometry. Mapping the in situ localization of 12,003 human proteins at a single-cell level to 30 subcellular structures enabled the definition of 13 major organelle proteomes. Exploration of the proteomes reveals single-cell variations of abundance or spatial distribution, and localization of approximately half of the proteins to multiple compartments. This subcellular map can be used to refine existing protein-protein interaction networks and provides an important resource to deconvolute the highly complex architecture of the human cell."
"So you thought single cell omics and the atlas was cool....… well, it's time to go subcellular ;-)" Eric Topol
Bringing RNA into the fold: Small molecules find new targets in RNA to combat disease Nature Medecine 05 May 2017
"The current landscape of RNA targeted drugs" Eric Topol
Cortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group Molecular Psychiatry 2 May 2017
Researchers create a roadmap of bipolar disorder and how it affects the brain MedicalXpress May 2, 2017
"By revealing clear and consistent alterations in key brain regions, the findings published in Molecular Psychiatry on May 2 offer insight to the underlying mechanisms of bipolar disorder."
CRISPR Eliminates HIV in Live Animals GEN News Highlights May 2, 2017
"Findings from the new study were published recently in Molecular Therapy in an article entitled “In Vivo Excision of HIV-1 Provirus by saCas9 and Multiplex Single-Guide RNAs in Animal Models.”"
FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans Cell Metabolism Volume 25, Issue 5, p1045–1053.e6, 2 May 2017
"The science behind a "sweet tooth" involves your liver" Eric Topol
Research moves closer to unravelling mystery cause of multiple sclerosis MedicalXpress April 24, 2017
More information: Yohannes Haile et al, Rab32 connects ER stress to mitochondrial defects in multiple sclerosis, Journal of Neuroinflammation (2017). DOI: 10.1186/s12974-016-0788-z
Research shows fish oil component helps damaged brain and retina cells survive MedicalXpress April 21, 2017
More information: Ludmila Belayev et al. Neuroprotectin D1 upregulates Iduna expression and provides protection in cellular uncompensated oxidative stress and in experimental ischemic stroke, Cell Death and Differentiation (2017). DOI: 10.1038/cdd.2017.55
Large-scale design of robust genetic circuits with multiple inputs and outputs for mammalian cells Nature Biotechnology 27 March 2017
Direct Brain Stimulation Modulates Encoding States and Memory Performance in Humans Current Biology 2017
‘Pacemaker’ for the Brain Can Help Memory, Study Finds The New York Times APRIL 20, 2017
"Pacemaker for the brain to boost memory?" Eric Topol
Cases of hepatitis B and C hit 325 million: WHO MedicalXpress April 21, 2017
1. "Carolyn's final thoughts: the diversity of talks highlight how central chemistry is to medicine, engineering, materials and beyond #ACSKCS"
2. "The gold standard in molecular recognition pairs has been biotin - (strep)avidin. Took a long time to beat it synthetically. ACSKCS See Last talk: Kimoon Kim @postech2020 on ultrastable synthetic binding pairs for biology. ACSKCS"
Macrophages Facilitate Electrical Conduction in the Heart Cell Volume 169, Issue 3, p510–522.e20, 20 April 2017
"Who would have ever thought macrophages conduct electricity in the heart?" Eric Topol
DNA's secret weapon against knots and tangles - A simple process seems to explain how massive genomes stay organized. But no one can agree on what powers it. Nature 19 April 2017
"The 3-D human genome and the enigmatic story if its loops" Eric Topol
Protein in human umbilical cord blood rejuvenates old mice's impaired learning, memory MedicalXpress April 19, 2017
More information: Human umbilical cord plasma proteins revitalize hippocampal function in aged mice, Nature (2017). nature.com/articles/doi:10.1038/nature22067
"Rejuvenating the aged brain using human cord umbilical plasma...how to make old mice smarter, v. provocative" Eric Topol
Precision Medicine Pioneer Targets Earlier Cancer Detection Medscape Monday, April 24, 2017
EricTopol's 1-on-1 w/ Dr Brian Druker
Data presentations will include platform sessions and posters across relapsing multiple sclerosis and primary progressive multiple sclerosis
The top 10 drug launches of 2017 FiercePharma Jan 30, 2017
Komodo dragon-inspired synthetic peptide DRGN-1 promotes wound-healing of a mixed-biofilm infected wound npj Biofilms and Microbiomes 2017 11 April 2017
Rapid screening machine can read and separate protein sequences Phys Org April 18, 2017
25 Clinical Failures of Q1 2017 GEN April 17, 2017
These 25 Drug Candidates Missed their Primary Endpoints, With Varying Consequences:
Tackling Weight Loss and Diabetes With Video Chats The New York Times APRIL 11, 2017
Interim look at data shows Roche hemophilia A drug cuts bleeds FierceBiotech Apr 17, 2017
Man moves paralyzed legs using device that stimulates spinal cord Mayo Clinic April 3, 2017
A new CRISPR breakthrough could lead to simpler, cheaper disease diagnosis The Washington Post April 13
In Vivo Interplay between p27Kip1, GATA3, ATOH1, and POU4F3 Converts Non-sensory Cells to Hair Cells in Adult Mice Cell Reports Volume 19, Issue 2, p307–320, 11 April 2017
"Another step forward towards restoration of hearing via gene therapy" Eric Topol
A curious connection: Teasing apart the link between gut microbes and lung disease Nature Medecine APRIL 2017
"Can manipulating the gut microbiome influence lung health? A few trials are trying to find out: More in new story"
FDA Approves 23andMe’s At-Home DNA Tests for 10 Diseases NBC News Apr 6 2017
The Accuracy of Heart Rate Monitoring by Some Wrist-Worn Activity Trackers Annals of Internal Medecine 18 April 2017
"Do wristbands sense heart rate accurately? It depends" Eric Topol
"Things you might ingest:" Eric Topol
- No, trans-fatty acids Hospital Admissions for Myocardial Infarction and Stroke Before and After the Trans-Fatty Acid Restrictions in New York JAMA Cardiology April 12, 2017
- No, resveratrol Effect of Resveratrol on Walking Performance in Older People With Peripheral Artery DiseaseThe RESTORE Randomized Clinical Trial JAMA Cardiology April 12, 2017
- ?, Multivitamin (I vote no)
"And this just out, a nice review on the past, present, and future of metal-catalyzed alkyl-alkyl bond formation" Steve Ritter
Olefination Baran Lab Decarboxylative alkenylation Nature 19 April 2017
A Tunable Diffusion-Consumption Mechanism of Cytokine Propagation Enables Plasticity in Cell-to-Cell Communication in the Immune System Immunity Volume 46, Issue 4, p609–620, 18 April 2017
"This paper is putting theory & experiment together to explain cytokine propagation. Answered a ton of my questions!" Alexandre Carisey
"This paper is putting theory & experiment together to explain cytokine propagation. Answered a ton of my questions" Alexandre Carisey
Harvard Professor takes Alzheimer’s fight personally YouTube April 2017
"Harvard Medical School Professor Reisa Sperling talks about the personal impact of Alzheimer’s disease, which killed both her father and grandfather. Sperling, a physician at Brigham and Women’s Hospital and director of the Center for Alzheimer’s Research and Treatment, is leading a multi-national study testing whether intervening before Alzheimer’s disease’s decline becomes apparent can make a difference in treatment."
Mutation of the Human Circadian Clock Gene CRY1 in Familial Delayed Sleep Phase Disorder Cell Volume 169, Issue 2, p203–215.e13, 6 April 2017
Normal sleep requires the astrocyte brain-type fatty acid binding protein FABP7 Gerstner et al., Sci. Adv. 2017;3: e1602663 5 April 2017
"Some nice advances this week in the genomics of sleep" Eric Topol
FDA Approves 23andMe’s At-Home DNA Tests for 10 Diseases NBC News Apr 6 2017
Financial math models may help build a better HIV vaccine MedicalXpress April 6, 2017
More information: Accurate predictions of population-level changes in sequence and structural properties of HIV-1 Env using a volatility-controlled diffusion model PLOS Biology (2017). DOI: 10.1371/journal.pbio.2001549
CRISPR-Cas: Adapting to change Science 07 Apr 2017
"There's been so much written about CRISPR genome editing, but here's an in-depth review on its immune defense role" Eric Topol
Stem cell patch shows early promise in treating heart failure Drug Target Review 6 April 2017
"Nearly 1 billion people smoke daily. New GBD study data published today on tobacco"
A Randomised Controlled Trial of Sodium Citrate Spray for Non-Conductive Olfactory Disorders Clinical Otolaryngology 24 March 2017
Sodium citrate spray could temporarily restore sense of smell MedicalXpress April 5, 2017
"A substance commonly used to treat bladder issues could temporarily treat people who have lost their sense of smell, according to research published in the journal Clinical Otolaryngology."
The ClusPro web server for protein–protein docking Nature Protocols 12 January 2017
Plotting the demise of Alzheimer's HARVARDgazette April 4, 2017
"Harvard researchers plot early attack against Alzheimer’s"
Machine learning predicts the look of stem cells Nature 05 April 2017
"Stunning image resource...here a dividing stem cell" Eric Topol
The FDA Can Declare War on Alzheimer’s The Wall Street Journal April 4, 2017
"No. I think we need better drugs, smarter trials, earlier start, biomarkers" Eric Topol
Area of the brain affected by autism detected MedicalXpress April 3, 2017
More information: Joshua H. Balsters et al. Disrupted prediction errors index social deficits in autism spectrum disorder, Brain (2016). DOI: 10.1093/brain/aww287
Stanford researchers create deep learning algorithm that could boost drug development Stanford News April 3, 2017
"Combining computer science and chemistry, researchers show how an advanced form of machine learning that works off small amounts of data can be used to solve problems in drug discovery."
Researcher creates chemical system that mimics early cell behavior Phys Org April 3, 2017
"Senior Research Fellow Juan Pérez-Mercader has published work on the development of a primeval-mimicking system that produces artificial "proto-cells" that grow, replicate, react to light, and even exhibit signs of natural selection"
More information: Anders N. Albertsen et al. Emergent Properties of Giant Vesicles Formed by a Polymerization-Induced Self-Assembly (PISA) Reaction, Scientific Reports (2017). DOI: 10.1038/srep41534
"An organized way to drug the genome"
"From all those genome wide association studies towards a "druggable genome" to rev up drug devp't/repurpsoing" Eric Topol
After 40-year odyssey, first drug for aggressive MS wins FDA approval STAT March 28, 2017
A Paralyzed Man Was Able to Move His Arm With His Brain TIME Mar 28, 2017
1. Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes Nature Immunology 27 March 2017
"Medicinal foods or metabolites might represent an effective and natural approach for countering the numerous immunological defects that contribute to T cell–dependent autoimmune diseases."
2. Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase Nature Chemical Biology 27 March 2017
1. Medicinal foods 2. Small molecule "Protection/reversal in diabetes?" Eric Topol
"Defying medical dogma: lungs as a source of blood cell production" Eric Topol
Stem cell therapy helps some men with erectile dysfunction MedicalXpress March 24, 2017
New study resolves the structure of the human protein that causes cystic fibrosis MedicalXpress March 23, 2017
Somatic mutations reveal asymmetric cellular dynamics in the early human embryo Nature 22 March 2017
"do de novo mutations occur in the early embryo? A very informative @Nature study by singerinstitute et al." Eric Topol
Treatment of Benzodiazepine Dependence NEJM March 23, 2017
"Long-term use of benzodiazepines can lead to dependence. Symptoms of withdrawal include anxiety, irritability, confusion, seizures, and sleep disorders. Withdrawal management relies on the use of a single agent (diazepam) and gradual dose reduction."
L’ADN d’un embryon humain a été corrigé Le Figaro 23/03/2017
"Les mutations ciblées, à l’origine de deux types d’anémie, la thalassémie bêta et le favisme, ont pu être réparées grâce à la technique de chirurgie du génome CRISPR-Cas9 au stade zygote (tout premier stade de développement de l’embryon, avec une seule cellule issue de la fusion de l’ovule et du spermatozoïde)."
Please see: CRISPR/Cas9-mediated gene editing in human zygotes using Cas9 protein Molecular Genetics and Genomics 01 March 2017
Microbes could make drug production more efficient Phys Org March 23, 2017
More information: Amy M Ehrenworth et al. Accelerating the semisynthesis of alkaloid-based drugs through metabolic engineering, Nature Chemical Biology (2017). DOI: 10.1038/nchembio.2308
Self-powered integrated microfluidic point-of-care low-cost enabling (SIMPLE) chip Science Advances 22 Mar 2017
"Impressive frugal innovation: Real time PCR microfluidic self-powered chip for low cost dx anywhere" Eric Topol
Sperm Counts via Your Cellphone The New york Times MARCH 22, 2017
Scientists develop a phone app that can track and analyze sperm STAT March 22, 2017
FDA approves drug to treat Parkinson’s disease FDA March 21, 2017
"The U.S. Food and Drug Administration today approved Xadago (safinamide) tablets as an add-on treatment for patients with Parkinson’s disease who are currently taking levodopa/carbidopa and experiencing “off” episodes. An “off” episode is a time when a patient’s medications are not working well, causing an increase in Parkinson’s symptoms, such as tremor and difficulty walking."
"What is your age-related risk of developing Alzheimer's ? A genetic risk score" Eric Topol
eGenesis bets on CRISPR to domesticate pig organs for safer xenotransplantation MedCityNews Mar 20, 2017
Transplant genetics and genomics Nature Reviews Genetics 2017
"Best review on omics I've seen" Eric Topol
Combinatorial CRISPR–Cas9 screens for de novo mapping of genetic interactions Nature Methods 2017
New blood biomarker could enhance early detection of heart attack risk FierceBiotech Mar 20, 2017
Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease NEJM March 17, 2013
"Long awaited PCSK9 Ab trial: relatively small benefit for heart attack & stroke in high risk patients" Eric Topol
Patients Lose Sight After Stem Cells Are Injected Into Their Eyes The New York Times MARCH 15, 2017
Light-generating reporter molecules ease cell monitoring Chemiluminescent reagents help track activity in cells CEN March 15, 2017
First steps in human DNA replication dance captured at atomic resolution Phys Org March 17, 2017
More information: "Structure of the active form of human origin recognition complex and its ATPase motor module" is published in eLife. The authors are: Ante Tocilj, Kin Fan On, Zuanning Yuan, Jingchuan Sun, Elad Elkayam, Huilin Li, Bruce Stillman and Leemor Joshua-Tor. elifesciences.org/content/6/e20818
Scientists zoom in on AIDS virus hideout MedicalXpress March 15, 2017
More information: Benjamin Descours et al. CD32a is a marker of a CD4 T-cell HIV reservoir harbouring replication-competent proviruses, Nature (2017). DOI: 10.1038/nature21710
A survey of working conditions within biomedical research in the United Kingdom [version 1; referees: awaiting peer review] F1000 Research 2017
"Hard work, low pay among scientists, post-docs -> disillusionment" Eric Topol
3-D X-ray imaging makes the finest details of a computer chip visible Phys Org March 16, 2017
More information: Mirko Holler et al. High-resolution non-destructive three-dimensional imaging of integrated circuits, Nature (2017). DOI: 10.1038/nature21698
Running away from Einstein Phys Org March 16, 2017
More information: Indranil Banik et al. Dynamical History Of The Local Group In ΛCDM slowromancapii@ − Including External Perturbers In 3D, Monthly Notices of the Royal Astronomical Society (2017). DOI: 10.1093/mnras/stx151
A dye-assisted paper-based point-of-care assay for fast and reliable blood grouping Science Translational Medicine 15 Mar 2017
"Frugal innovation: paper testing for fast (30 sec-2 min), accurate blood group ABO and Rh determination" Eric Topol
Polar Extremes in the Clinical Use of Stem Cells N Engl J Med 2017; 376:1075-1077
"Induced pluripotent stem cells (iPSC)—trying to prevent blindness (done right) vs inducing blindness (done wrong)" Eric Topol
Researchers make major brain repair discovery in fight against multiple sclerosis MedicalXpress rch 15, 2017
More information: Yvonne Dombrowski et al. Regulatory T cells promote myelin regeneration in the central nervous system, Nature Neuroscience (2017). DOI: 10.1038/nn.4528
Imaging at the speed of light Phys Org March 14, 2017
"Researchers at the University of Rochester's Institute of Optics developed a technique to visualize, for the first time, the complete evolution of micro- and nanoscale structural formation on a material's surface both during and after the application of a laser pulse"
Nrl knockdown by AAV-delivered CRISPR/Cas9 prevents retinal degeneration in mice Nature Communications 2017
""Free Blind Mice"—another in vivo success story for CRISPR genome editing" Eric Topol
Eating lots of cheese does not raise cholesterol, study shows Medical Xpress March 14, 2017
More information: E L Feeney et al. Patterns of dairy food intake, body composition and markers of metabolic health in Ireland: results from the National Adult Nutrition Survey, Nutrition & Diabetes (2017). DOI: 10.1038/nutd.2016.54
Genetics of coronary artery disease: discovery, biology and clinical translation Nature Reviews Genetics 2017
"The genomics of coronary artery disease, a new review by the leaders" Eric Topol
Major research project provides new clues to schizophrenia MedicalXpress March 14, 2017
"Lower levels of the glial cell marker TSPO in drug-naive first-episode psychosis patients as measured using PET and [11C]PBR28". Collste K, Plavén-Sigray P, Fatouros-Bergman H, Victorsson P, Schain M, Forsberg A, Amini N, Aeinehband S, Karolinska Schizophrenia Project (KaSP) consortium, Erhardt S, Halldin C, Flyckt L, Farde L, Cervenka S. Molecular Psychiatry, online 14 February 2017. DOI: 10.1038/mp.2016.247
3D structures of individual mammalian genomes studied by single-cell Hi-C Nature 13 March 2017
"3-D genomes of single cells: a technological and dataviz feat! ✓out the video" Eric Topol
Management of Type 2 Diabetes in 2017Getting to Goal JAMA March 14, 2017
Pharmacologic Therapy for Type 2 Diabetes: Synopsis of the 2017 American Diabetes Association Standards of Medical Care in Diabetes Annals of Internal Medecine 2017
"Managing diabetes in 2017: 2 v good summaries" Eric Topol
A kiss of death to drug the 'undruggable' Phys Org March 13, 2017
More information: Structural basis of PROTAC cooperative recognition for selective protein degradation, Nature Chemical Biology, nature.com/articles/doi:10.1038/nchembio.2329
Phage therapy shown to kill drug-resistant superbug Phys Org March 13, 2017
New estimate of ocean heat finds more warming Phys Org March 13, 2017
More information: Lijing Cheng et al. Improved estimates of ocean heat content from 1960 to 2015, Science Advances (2017). DOI: 10.1126/sciadv.1601545
"In other words, the planet is warming quite a lot more than we thought," said NCAR scientist Kevin Trenberth, a study co-author.
Hair Loss Drug Propecia Carries Risk of Losing Something Else NBC News Mar 10 2017
"Two drugs used to treat both hair loss and prostate problems could carry another risk that men might want to know about: long-term sexual problems."
The Top 15 Best-Selling Drugs of 2016 GEN March 06, 2017
New Enzyme-Like Tool Lets Chemists Modify Hard-to-Reach Spots on Drug Molecules LA JOLLA, CA – March 8, 2017
TSRI chemist Jin-Quan Yu looks to mimic enzymes found in nature-but make them even more versatile
Depression may be biggest cause of lost productivity with sinus problems Reuters Health News March 2017
New technology offers fast peptide synthesis Phys Org February 27, 2017
""You can dial in whatever amino acids you want, and the machine starts printing off these peptides faster than any machine in the world," says Bradley Pentelute, the Pfizer-Laubach Career Development Associate Professor of Chemistry at MIT."" ""We can start thinking about a personalized chemistry machine," Pentelute says. "It's modular and it's adaptable to all sorts of other chemistries."
More information: A fully automated flow-based approach for accelerated peptide synthesis, Nature Chemical Biology, nature.com/articles/doi:10.1038/nchembio.2318
Biotech dreams of drugging the ‘undruggable’ STAT February 27, 2017
Study provides clues to relationship between schizophrenia and rheumatoid arthritis MedicalXpress February 24, 2017
More information: Tulsi A. Malavia et al. Generating testable hypotheses for schizophrenia and rheumatoid arthritis pathogenesis by integrating epidemiological, genomic, and protein interaction data, npj Schizophrenia (2017). DOI: 10.1038/s41537-017-0010-z
Mechanisms for initiating cellular DNA replication Science 24 Feb 2017
"The nitty-gritty of DNA replication: excellent graphics" Eric Topol
10 Breakthrough Technologies 2017 MIT New Technology 2017
"Always interesting to see techreview's top 10 breakthroughs" Eric Topol
Three-in-one design allows genetic, chemical, optical, and electrical inputs and outputs MedicalXpress February 22, 2017
More information: Seongjun Park et al. One-step optogenetics with multifunctional flexible polymer fibers, Nature Neuroscience (2017). DOI: 10.1038/nn.4510
Apitope’s Phase II multiple sclerosis trial a success European Pharmaceutical Review 22 February 2017
Future life expectancy in 35 industrialised countries: projections with a Bayesian model ensemble The Lancet 21 February 2017
"Ready for life expectancy to jump to 90? especially likely in women by 2030 in these countries... impressive analysis" Eric Topol
Years of potential life lost and life expectancy in schizophrenia: a systematic review and meta-analysis The Lancet Psychiatry 21 February 2017
"People with schizophrenia lose 13–15 years of potential life...These values seemed not to have improved over time."
Scientists Create Active Controllable Electronic DNA Switch GEN News Highlights February 21, 2017
Understanding how HIV evades the immune system MedicalXpress February 21, 2017
More information: Nature Structural and Molecular Biology, DOI: 10.1038/nsmb.3381
Creative people have better-connected brains, research finds MedicalXpress February 21, 2017
More information: Daniele Durante et al. Bayesian Inference and Testing of Group Differences in Brain Networks, Bayesian Analysis (2016). DOI: 10.1214/16-BA1030
Start codons in DNA may be more numerous than previously thought Phys Org February 21, 2017
More information: Nucleic Acids Research (2017). DOI: 10.1093/nar/gkx070
MS treatment that 'resets' immune system may halt disease progression for at least five years MedicalXpress February 20, 2017
More information: JAMA Neurol. Published online February 20, 2017. doi:10.1001/jamaneurol.2016.5867
"Can autologous stem cell transplant "reset" the immune system & help multiple sclerosis Rx?" Eric Topol
Smartphones are revolutionizing medicine Phys Org February 18, 2017
Channeling chip power: Tissue chips are being put to the test by industry Nature Medecine FEB 2017
'Smart' mobile tool may be used to diagnose and treat serious diseases Phys Org February 16, 2017
More information: Zachary S. Ballard et al. Computational Sensing Using Low-Cost and Mobile Plasmonic Readers Designed by Machine Learning, ACS Nano (2017). DOI: 10.1021/acsnano.7b00105
Researchers find autism biomarkers in infancy MedicalXpress February 15, 2017
More information: Nature, nature.com/articles/doi:10.1038/nature21369
Imaging technique for unique views of single molecules that conventional methods can't match Phys Org February 15, 2017
More information: Ashok Ajoy et al. Quantum interpolation for high-resolution sensing, Proceedings of the National Academy of Sciences (2017). DOI: 10.1073/pnas.1610835114
Psychiatric drugs haven’t improved for decades. So researchers are scouring the brain for leads STAT NEWS February 15, 2017
Muscle-specific CRISPR/Cas9 dystrophin gene editing ameliorates pathophysiology in a mouse model for Duchenne muscular dystrophy Nature Communications 14 February 2017
"One more CRISPR-ing in vivo genome editing demonstration, in muscular dystrophy model" Eric Topol
Sharp Rise Reported in Older Americans’ Use of Multiple Psychotropic Drugs The New York Times FEB. 13, 2017
Modifying methionine on proteins - Redox chemistry turns reticent amino acid into bioconjugation handle CEN February 9, 2017
New Protein Tow Hitch Juts from Other Sulfur CEN News Highlights February 10, 2017
Researchers find clues to why diet with olive oil is tied lower heart disease risk Reuters Feb 13, 2017
“Our hypothesis is that these dietary antioxidants may bind to HDL particles and protect them against different kinds of attacks,” Hernáez said by email. “As HDLs are more protected, they can perform their biological functions more efficiently and, therefore, they are able to remove cholesterol from arteries or contribute to the relaxation of blood vessels for longer.” "High levels of low density lipoproteins (LDL) or “bad” cholesterol and fats known as triglycerides are associated with an increased risk of heart and blood vessel diseases. HDL, or “good,” cholesterol is associated with a lower risk because it helps remove excess LDL from the bloodstream."
Seq-Well: portable, low-cost RNA sequencing of single cells at high throughput Nature Methods 13 February 2017
"Single-Cell RNA-seq at scale?" Eric Topol
The Chemical Compounds Behind the Smell of Flowers "Giving flowers for Valentine's Day tomorrow? Here's a look at some of the major contributors to their aromas!"
Giving flowers for Valentine's Day tomorrow? Here's a look at some of the major contributors to their aromas!
Forebrain-selective AMPA-receptor antagonism guided by TARP γ-8 as an antiepileptic mechanism Nature Medecine Dec 2016
"LY3130481 is a novel anti-epileptic drug that lacks motor impairment side-effects"
What's chocolate, and how does its chemistry inspire such cravings? CEN February 7, 2017
Hundreds of chemicals make chocolate so delicious, and it was once a currency you could eat "Chemistry of chocolate." ACS Central Science
New discovery could be a major advance for neurological diseases MedicalXpress February 13, 2017
More information: Metabotropic action of postsynaptic kainate receptors triggers hippocampal long-term potentiation, Nature Neuroscience, nature.com/articles/doi:10.1038/nn.4505
New protein discovery may lead to new, natural antibiotics Phys Org February 13, 2017
More information: Jonathan R. Goodson et al, LoaP is a broadly conserved antiterminator protein that regulates antibiotic gene clusters in Bacillus amyloliquefaciens, Nature Microbiology (2017). DOI: 10.1038/nmicrobiol.2017.3
DNA repair—a new letter in the cell alphabet Phys Org February 13, 2017
More information: Juan José Bonfiglio et al. Serine ADP-Ribosylation Depends on HPF1, Molecular Cell (2017). DOI: 10.1016/j.molcel.2017.01.003
A Spec-tacular method to determine physicochemical properties of drug molecules ACS Cent. Sci., 2017
"A Spec-tacular method to determine physicochemical properties of drug molecules"
Mapping the mind: A new tool reveals uncharted territories in the brain Nature Medecine 2017
"A new tool for mapping the brain, NeuroGrid" Eric Topol
FDA approves drug to treat Duchenne muscular dystrophy Reuters Feb 9, 2017
Genetics of both virus and patient work together to influence the course of HIV infection MedicalXpress February 9, 2017
More information: Bartha I, McLaren PJ, Brumme C, Harrigan R, Telenti A, Fellay J (2017) Estimating the Respective Contributions of Human and Viral Genetic Variation to HIV Control. PLoS Comput Biol 13(2): e1005339. DOI: 10.1371/journal.pcbi.1005339
Four Artificial Pancreas Trials for Type 1 Diabetes Move Forward TIME Feb 08, 2017
Twins study: How one-year mission affected astronaut's health CNN February 3, 2017
"Yet another CRISPR cure; genome editing in vivo experimental model" Eric Topol
'Gene for speed' linked to severity and progression of Duchenne muscular dystrophy MedicalXpress February 3, 2017
"Scientists from the Murdoch Childrens Research Institute (MCRI) have discovered that a gene linked to performance in elite athletes also influences disease severity in Duchenne muscular dystrophy (DMD), the most common inherited muscle disease that affects around one in 3,500 boys."
More information: Marshall W. Hogarth et al. Evidence for ACTN3 as a genetic modifier of Duchenne muscular dystrophy, Nature Communications (2017). DOI: 10.1038/ncomms14143
Want to Prevent Alzheimer’s? Eat Grapes! CEN February 6, 2017
The Purpose of Sleep? To Forget, Scientists Say The New York Times FEB. 2, 2017
"Consuming grapes twice a day for 6 months protected against significant metabolic decline in Alzheimer-related areas of the brain in a study of people with early memory decline."
The Brain’s Connections Shrink During Sleep The Atlantic FEB. 2, 2017
"What sleep does for brain synapses" Eric Topol
Chemists unveil versatile new method for making chiral drug molecules Phys Org February 2, 2017
More information: "Formation of α-chiral centers by asymmetric β-C(sp3)-H arylation, alkenylation, and alkynylation," Science science.sciencemag.org/cgi/doi/10.1126/science.aal5175
ON MESSAGE Moderna Therapeutics has raised nearly $2 billion to turn RNA into a new kind of drug. Can it live up to the hype? Science Magazine 3 FEBRUARY 2017
"2 outstanding artificial intelligence in medicine studies AI" Eric Topol
Market watch: Value of 2016 FDA drug approvals: reversion to the mean? Nature Reviews Drug Discovery 2017
Scientists identify two brain networks influencing how we make decisions MedicalXpress February 2, 2017
More information: Damian M Herz et al, Distinct mechanisms mediate speed-accuracy adjustments in cortico-subthalamic networks, eLife (2017). DOI: 10.7554/eLife.21481
Doctors save Canadian woman's life by removing her lungs for six days The Guardian Wednesday 25 January 2017
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk Nature Genetics 30 January 2017
"A genomics bonanza for high blood pressure yields > 100 new common variants" Eric Topol
An artificial intelligence platform for the multihospital collaborative management of congenital cataracts Nature Biomedical Engineering 30 January 2017
"When artificial intelligence=doctor's abilities (again) +data share" Eric Topol
Scientists take first steps to grow human organs in pigs CBS News January 26, 2017
New Prospects for Growing Human Replacement Organs in Animals The New York Times JAN. 26, 2017
Are New Drugs for Hepatitis C Safe? A Report Raises Concerns The New York Times JAN. 24, 2017
"Drugs that can cure hepatitis C may have severe side effects, including liver failure"
SnapShot: The Noncanonical Inflammasome Cell 26 January 2017
"Nice graphic of the inflammasome, our sensor to detect certain pathogens" Eric Topol
Advance in high-pressure physics - Harvard scientists announce they've created metallic hydrogen, which has been just a theory HARVARDgazette January 26, 2017
Neuroscience: Big brain, big data Nature 25 January 2017
"The brain's bigdata: challenges and openscience" Eric Topol
Towards a smart medical home The Lancet 28 January 2017
"Towards the smart medical home Our latest @TheLancet digital medicine essay" Eric Topol
These twin baby girls have different skin colors CNN January 25, 2017
Abnormal neurogenesis and cortical growth in congenital heart disease Science Translational Medicine 25 Jan 2017
"Why kids w/congenital heart disease have neurologic deficits? an elegant study" Eric Topol
Prevalence and architecture of de novo mutations in developmental disorders Nature 25 January 2017
"Largest study genomics development disorders : 14 new conditions, importance of old dads ++" Eric Topol
Mature heart muscle cells created in the laboratory from stem cells MedicalXpress January 26, 2017
More information: Gun-Sik Cho et al, Neonatal Transplantation Confers Maturation of PSC-Derived Cardiomyocytes Conducive to Modeling Cardiomyopathy, Cell Reports (2017). DOI: 10.1016/j.celrep.2016.12.040
New clues on the base of Parkinson's disease and other 'synucleinopathies' MedicalXpress January 25, 2017
More information: In situ proteomic approaches connect alpha synuclein directly to endocytic trafficking and mRNA metabolism in neurons, Cell Systems, online January 25, 2017.
Light microscopy provides a deep look into protein structure Phys Org January 25, 2017
More information: Siegfried Weisenburger et al. Cryogenic optical localization provides 3D protein structure data with Angstrom resolution, Nature Methods (2017). DOI: 10.1038/nmeth.4141
"A clever, individualized strategy for smoking cessation doubles the success rate" Eric Topol
Team identifies tuberculosis drug and dose regimen that may cut time by up to 75 percent MedicalXpress January 25, 2017
Bai-Yu Lee et al. Drug regimens identified and optimized by output-driven platform markedly reduce tuberculosis treatment time, Nature Communications (2017). DOI: 10.1038/ncomms14183
'The sun is not your friend': Woman's painful tan warning goes viral TODAY Jan. 24, 2017
One small step... Disagreements over the definition of a chemical step underlie much broader questions Chemistry World 24 January 2017
Gut microbe study shows promise as a potential treatment for autism ASU Now: Access, Excellence, Impact Jan 23, 2017
"Gut microbe study shows promise as a potential treatment for autism"
"Bound to be controversial: fecal transplants to Δ microbiome for autism" Eric Topol
"What a single saturated fat load can do to hurt the liver (wow)" Eric Topol
Big-data approaches to protein structure prediction Science 20 Jan 2017
K"now when (where) to fold 'em: big data, mutations & protein structure" Eric Topol
Soft robot helps the heart beat HARVARDgazette January 20, 2017
"Sleeve attaches directly around the heart"
Researchers have developed a customizable soft robot that fits around the heart and helps it beat
These Microscopic Bots Could Swim through the Bloodstream Scientific American February 2017
Chemists create micro swimmers that can be controlled by light
Programmable artificial phototactic microswimmer Nature Nanotechnology 2017
"Microscopic robots in your bloodstream" Eric Topol
Scaling single-cell genomics from phenomenology to mechanism Nature 18 January 2017
"We're learning a lot from single cell genomics, and this is an excellent review" Eric Topol
Scientists develop first catalysed reaction using iron salts Phys Org January 20, 2017
More information: Kirsty Adams et al. An iron-catalysed C–C bond-forming spirocyclization cascade providing sustainable access to new 3D heterocyclic frameworks, Nature Chemistry (2016). DOI: 10.1038/nchem.2670
Applications of chemogenomic library screening in drug discovery Nature Reviews Drug Discovery 2017
Chemists cook up new nanomaterial and imaging method Phys Org January 20, 2017
"A team of chemists led by Northwestern University's William Dichtel has cooked up something big: The scientists created an entirely new type of nanomaterial and watched it form in real time—a chemistry first."
More information: Brian J. Smith et al. Colloidal Covalent Organic Frameworks, ACS Central Science (2017). DOI: 10.1021/acscentsci.6b00331
T memory stem cells in health and disease Nature Medicine 06 January 2017
"Everything you always wanted to know about T memory stem cells and more" Eric Topol
Gecko inspired adhesive can attach and detach using UV light Phys Org January 19, 2017
More information: Emre Kizilkan et al. Bioinspired photocontrollable microstructured transport device, Science Robotics (2017). DOI: 10.1126/scirobotics.aak9454
First cell culture of live adult human neurons shows potential of brain cell types MedicalXpress January 17, 2017
See how immune cells break through blood vessel walls MedicalXpress January 17, 2017
More information: Cell Reports, Barzilai et al.: "Leukocytes breach endothelial barriers by insertion of nuclear lobes and disassembly of endothelial actin filaments" http://www.cell.com/cell-reports/fulltext/S2211-1247(16)31798-3 , DOI: 10.1016/j.celrep.2016.12.076
Every meal triggers inflammation MedicalXpress January 17, 2017
More information: Erez Dror et al. Postprandial macrophage-derived IL-1β stimulates insulin, and both synergistically promote glucose disposal and inflammation, Nature Immunology (2017). DOI: 10.1038/ni.3659
Major advance in the understanding of the transport of RNA Phys Org January 17, 2017
"Messenger RNAs bearing the genetic information for the synthesis of proteins are delivered to defined sites in the cell cytoplasm by molecular motors. LMU researchers have elucidated how the motors recognize their mRNA freight."
More information: Franziska Theresia Edelmann et al. Molecular architecture and dynamics of ASH1 mRNA recognition by its mRNA-transport complex, Nature Structural & Molecular Biology (2017). DOI: 10.1038/nsmb.3351
A natural compound can block the formation of toxins associated with Parkinson's disease MedicalXpress January 16, 2017
"A naturally-occurring compound has been found to block a molecular process thought to underlie Parkinson's Disease, and to suppress its toxic products, scientists have reported."
More information: A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity, PNAS, www.pnas.org/cgi/doi/10.1073/pnas.1610586114
Interactions between the microbiota, immune and nervous systems in health and disease Nature Neuroscience 16 January 2017
"2 excellent reviews on the brain & immune system, this one + microbiome" Eric Topol
Study Maps ‘Uniquely Devastating’ Genital Injuries Among Troops The New York Times JAN. 13, 2017
Scientists crack the structure of HIV machinery Phys Org January 5, 2017
"Salk Institute scientists have solved the atomic structure of a key piece of machinery that allows HIV to integrate into human host DNA and replicate in the body, which has eluded researchers for decades. The findings describing this machinery, known as the "intasome," appear January 6, 2017, in Science and yield structural clues informing the development of new HIV drugs."
More information: "Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome" Science, science.sciencemag.org/cgi/doi/10.1126/science.aah5163
What does it take for an AIDS virus to infect a person? MedicalXpress January 10, 2017
"Upon sexual exposure, the AIDS virus must overcome some mighty barriers to find the right target cell and establish a new infection. It must traverse the genital mucosa and squeeze through tightly packed epithelial cells meant to keep invaders out. And then it must thwart the initial immune-system alarm bell in the form of type 1 interferons. In fact, according to some studies, only about 1 in 1,000 unprotected sexual exposures lead to a successful HIV-1 infection."
More information: Resistance to type 1 interferons is a major determinant of HIV-1 transmission fitness, PNAS, www.pnas.org/cgi/doi/10.1073/pnas.1620144114
Study reveals way to design key protein-binding structures Phys Org January 13, 2017
"This method opens the door to the design of new proteins capable of entirely new functions, including catalyzing reactions not seen in nature, and has many potential applications, including the development of new diagnostic tests and treatments."
More information: Enrique Marcos et al. Principles for designing proteins with cavities formed by curved β sheets, Science (2017). DOI: 10.1126/science.aah7389
Chemist develops new theory for explaining the function of proteins Phys Org January 13, 2017
More information: Ashkan Fakharzadeh et al. Effective Riemannian Diffusion Model for Conformational Dynamics of Biomolecular Systems, The Journal of Physical Chemistry Letters (2016). DOI: 10.1021/acs.jpclett.6b02208
Study Maps ‘Uniquely Devastating’ Genital Injuries Among Troops The New York Times Jan 13, 2017
First 3-D platform for simulating zebrafish behavior may replace animals in some research Phys Org January 13, 2017
More information: Violet Mwaffo et al, In-silico experiments of zebrafish behaviour: modeling swimming in three dimensions, Scientific Reports (2017). DOI: 10.1038/srep39877
3-D antibody arrays offer better sensing - New tool could help diagnose malaria and other diseases MIT News January 4, 2017
"MIT chemical engineers discovered that they could force antibodies and other proteins to form layers by attaching each protein to a polymer tail. The proteins and polymers repel each other, so the molecules arrange themselves in a structure that minimizes the interactions between the protein and polymer segments."
Removal of multiple contaminants from water by supported ionic liquid phases Phys Org January 13, 2017
More information: Sven Herrmann et al. Removal of Multiple Contaminants from Water by Polyoxometalate-Supported Ionic Liquid Phases (POM-SILPs), Angewandte Chemie International Edition (2017). DOI: 10.1002/anie.201611072
Improving longevity of functionally integrated stem cells in regenerative vision therapy MedicalXpress January 12, 2017
"Publishing in the Cell Stem Cell, this work highlights immune system rejection as one of the key issues that needs to be addressed to improve efficiency of stem cell regeneration therapies."
More information: Immunosuppression via loss of IL2r enhances long-term functional integration of hESC-derived photoreceptors in the mouse retina, Cell Stem Cell, DOI: 10.1016/j.stem.2016.11.0193
"An outstanding review of CRISPR genome editing technologies" Eric Topol
Exercise... It does a body good: 20 minutes can act as anti-inflammatory MedicalXpress January 12, 2017
More information: Stoyan Dimitrov et al, Inflammation and exercise: Inhibition of monocytic intracellular TNF production by acute exercise via β2-adrenergic activation, Brain, Behavior, and Immunity (2016). DOI: 10.1016/j.bbi.2016.12.017
How smartphones are transforming healthcare - Powerful new apps are turning our phones into mobile medical clinics. Could this help solve the issue of rising healthcare costs? Financial Time Magazine January 12, 2017
"How your phone is becoming your doctor" Eric Topol
The Essential Medicinal Chemistry of Curcumin J Med Chem 2017
"Could the golden child of the spice world actually be fool’s gold?"
"How to reduce the hospital microbiome vulnerability in the future" Eric Topol:
The hospital of tomorrow is in a patient’s home By Eric J. Topol, M.D. | January 9, 2017 | Opinion
Mapping the Microorganisms Behind Hospital-Borne Infections - A new project could help protect patients by showing how microbes move throughout hospitals.
- Understanding the role of cell-type-specific changes in human brain aging
"Our brain deterioration, glia and biological age" Eric Topol
What does it take for an AIDS virus to infect a person? MedicalXpress January 10, 2017
"In fact, according to some studies, only about 1 in 1,000 unprotected sexual exposures lead to a successful HIV-1 infection."
More information: Resistance to type 1 interferons is a major determinant of HIV-1 transmission fitness, PNAS, www.pnas.org/cgi/doi/10.1073/pnas.1620144114
"Digitizing 150 years of history using artificial intelligence" Eric Topol
T memory stem cells in health and disease Nature Medicine Review 06 January 2017
"T memory stem (TSCM) cells are a rare subset of memory lymphocytes endowed with the stem cell–like ability to self-renew and the multipotent capacity to reconstitute the entire spectrum of memory and effector T cell subsets."
Arrhythmogenic Right Ventricular Cardiomyopathy NEJM January 5, 2017
"A superb review of an important cause of sudden cardiac death: ARVD" Eric Topol
Captured on video: DNA nanotubes build a bridge between two molecular posts Phy Org January 5, 2017
More information: Abdul M. Mohammed et al, Self-assembling DNA nanotubes to connect molecular landmarks, Nature Nanotechnology (2016). DOI: 10.1038/nnano.2016.277
Scientists crack the structure of HIV machinery Phys Org January 5, 2017
"Salk Institute scientists have solved the atomic structure of a key piece of machinery that allows HIV to integrate into human host DNA and replicate in the body, which has eluded researchers for decades. The findings describing this machinery, known as the "intasome," appear January 6, 2017, in Science and yield structural clues informing the development of new HIV drugs."
More information: "Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome" Science, science.sciencemag.org/cgi/doi/10.1126/science.aah5163
Innate and adaptive immune traits are differentially affected by genetic and environmental factors Nature Communications 05 January 2017
"The genetic influence on our adaptive immunity is greater than expected" Eric Topol
Genetics play a significant role in immunity, new research finds MedicalXpress January 5, 2017
"A relatively large segment of an urban population lives unaware of severe emergency levels of hypertension. A public mobile hypertension clinic provides a valuable strategy for identifying hypertension in the general public and for knowledge translation of hypertension management."
"The "alarming" rate of silent and uncontrolled hypertension diagnosed by mobile clinic [50%]" Eric Topol
Will artificial intelligence help to crack biology? The Economist Jan 7th 2017 "Yes, it can't hurt" Eric Topol
Silicon Valley has the squidgy worlds of biology and disease in its sights
Nanotechnology enables new insights into chemical reactions Phys Org January 5, 2017
More information: Waiz Karim et al. Catalyst support effects on hydrogen spillover, Nature (2017). DOI: 10.1038/nature20782
Bipolar disorder and epilepsy linked to turning down an inhibitory switch in brain circuits MedicalXpress January 4, 2017
Powerful anti-inflammatory molecule may block vision loss in diabetic retinopathy MedicalXpress January 3, 2017
Imaging as the Nidus of Precision Cerebrovascular HealthA Million Brains Initiative JAMA Neurology January 03, 2017
"Brain imaging, precision medicine, & the digital health revolution" Eric Topol
SELECTED MISCELLEANEOUS PUBLICATIONS 2016
Scientists replace piece of gene mutated in Duchenne muscular dystrophy in effort to make healthy MedicalXpress December 19, 2016
Industrialising organoids for the next generation of drug discovery Drug Target Review 20 December 2016
"New synthetic 3D gel technology for cell culture promises to unlock the potential of ‘mini-organs’ for industrial drug discovery"
Roche’s emicizumab for haemophilia A meets primary endpoint in phase III study Roche 22 December 2016
"Emicizumab prophylaxis reduced the number of bleeds over time compared to no prophylaxis in people with haemophilia A and inhibitors to factor VIII"
New CRISPR–Cas systems from uncultivated microbes Nature 22 December 2016
"Nature is made for genome editing A new CRISPR system discovered" Eric Topol
Cornerstones of CRISPR–Cas in drug discovery and therapy Nature Reviews Drug Discovery 23 December 2016
"Good things happen when 7 leading academic centers share data on a RareDisease" Eric Topol
B-Cell Depletion — A Frontier in Monoclonal Antibodies for Multiple Sclerosis NEJM December 21, 2016
"Multiple sclerosis is a disabling autoimmune disease in which immune cells target central nervous system (CNS) antigens, leading to demyelination, glial activation, and subsequent loss of neurons and axons."
The Charcot Lecture | Beating MS: A story of B cells, with twists and turns SAGE Journal December 5, 2014
"Challenging T-cell centric thinking for multiple sclerosis" Eric Topol
Oligonucleotide Therapeutics Near Approval The Scientist December 1, 2016
"Successful late-stage clinical trials could mark the maturation of a new drug development platform, but the path to commercialization is not without hurdles."
"Oligonucleotide therapeutics are being hailed as the third major drug-development platform after small molecules and biologics."
"10-20 yrs later oligonucleotides are starting to take hold as viable therapies" Eric Topol
Mitochondrial Donation — Clearing the Final Regulatory Hurdle in the United Kingdom NEJM December 28, 2016
Heat-activated penile implant might restore sexual function in men with ED MedicalXpress December 29, 2016
"The basic technology for penile implants hasn't improved much in 40 years."
"But Brian Le, a new faculty member in the Department of Urology with a background in materials science, is hoping that a heat-activated memory metal called Nitinol (a nickel-titanium alloy) will create a better implant for men with erectile dysfunction."
"Towards understanding how the gut microbiome induces autoimmune diseases" Eric Topol
In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming Cell 15 December 2016 & Influence of donor age on induced pluripotent stem cells Nature Biotechnology 12 December 2016
"2 San Diego papers this wk highlight epigenome <-> aging interaction" Eric Topol
Bursts of Reprogramming: A Path to Extend Lifespan? Cell 15 December 2016
"A diagram that nicely summarizes the major anti-aging strategies underway" Eric Topol
Scientists replace piece of gene mutated in Duchenne muscular dystrophy in effort to make healthy MedicalXpress December 19, 2016
""We want to use genetically corrected stem cells to replace the stem cell pool and make new muscles that function normally," said Dr. Yaoliang Tang, cardiovascular researcher in the Vascular Biology Center at the Medical College of Georgia at Augusta University."
The world’s tiniest radio HarvardGazette December 16, 2016
"Researchers have built the world’s tiniest radio — whose building blocks are the size of two atoms"
Scalable Synthesis of (−)-Thapsigargin ACS Cent. Sci. 2016
BaranLabReads "They can all be made in 11-steps. Read about our last total synthesis of 2016 here"
11-Step Synthesis of (–)-Thapsigargin Baran Lab Blog
"What is a step anyway? A deep-dive into that question prompted by Thapsigargin and some interesting referee comments"
"Sequencing finds a movement disorder's genomic basis, amenable to DBS treatment" Eric Topol
GSK's two-drug HIV therapy shines in two big studies Reuters Dec 20, 2016
"GSK has developed the new two-drug cocktail through its majority-owned ViiV Healthcare, in which Pfizer and Shionogi also hold stakes. The aim is to offer the two-drug regimen as a single tablet."
Synthesizing a five-membered ring nitrogen compound Phys Org December 20, 2016
More information: Brad A. Steele et al. High-Pressure Synthesis of a Pentazolate Salt, Chemistry of Materials (2016). DOI: 10.1021/acs.chemmater.6b04538
Study shows how brain begins repairs after 'silent strokes' MedicalXpress December 20, 2016
More information: Elif G. Sozmen et al. Nogo receptor blockade overcomes remyelination failure after white matter stroke and stimulates functional recovery in aged mice, Proceedings of the National Academy of Sciences (2016). DOI: 10.1073/pnas.1615322113
Novel technique helps ID elusive molecules Phys Org December 21, 2016
Video: "Here, the technique of recognition tunneling is used to sequence protein and peptide molecules. In the current study, a similar method is described for the rapid and accurate identification of carbohydrate molecules. Credit: The Biodesign Institute at Arizona State University"
10 Tech Advances That Can Change Medicine Mescape December 16, 2016
"My 2016 Top 10 of tech that can change medicine" Eric Topol
One in 6 American Adults Say They Have Taken Psychiatric Drugs, Report Says The New York Times Dec 12, 2016
"A low cost, mobile device for rapid bacterial pathogen detection anywhere" Eric Topol
Cellular reprogramming reverses signs of aging MedicalXpress December 15, 2016
"the team used the same short reprogramming method during cyclic periods in live mice with progeria. The results were striking: Compared to untreated mice, the reprogrammed mice looked younger; their cardiovascular and other organ function improved and—most surprising of all—they lived 30 percent longer, yet did not develop cancer. On a cellular level, the animals showed the recovery of molecular aging hallmarks that are affected not only in progeria, but also in normal aging."
More information: Cell, Ocampo et al.: "In vivo amelioration of age-associated hallmarks by partial reprogramming." DOI: 10.1016/j.cell.2016.11.052 , www.cell.com/cell/fulltext/S0092-8674(16)31664-6
Fountain-of-youth molecules make mice young again, extending their lives STAT December 15, 2016
"In mice that were genetically engineered to have progeria, the molecules extended their lifespan by an average of one-third: from 18 weeks to 24. The animals’ spleens, skin, kidneys, blood vessels, and stomachs all looked and acted younger, such as by regaining the ability to regenerate cells. Even the mice’s spine curvature — like the “dowager’s hump” that some elderly women develop — was reduced."
Adult Utilization of Psychiatric Drugs and Differences by Sex, Age, and Race JAMA Internal Medecine December 12, 2016
"1 of 6 Americans taking psychiatric medications" Eric Topol
Feasibility of Obtaining Measures of Lifestyle From a Smartphone AppThe MyHeart Counts Cardiovascular Health Study JAMA Cardiology December 14, 2016
"A mobile app to assess cardiovascular health in > 40,000 people" Eric Topol
Skin cells 'crawl' together to heal wounds treated with unique hydrogel layer MedicalXpress December 14, 2016
"Time may not heal all wounds, but a proprietary mix of peptides and gel developed by U of T Engineering researchers heals most."
More information: Yun Xiao et al, Diabetic wound regeneration using peptide-modified hydrogels to target re-epithelialization, Proceedings of the National Academy of Sciences (2016). DOI: 10.1073/pnas.1612277113
Solving Immunology? Trends in Immunology 2016
"Here, we present the perspectives that emerged from the National Institute of Allergy and Infectious Disease (NIAID) workshop ‘Complex Systems Science, Modeling and Immunity’ and subsequent discussions regarding the potential synergy of high-throughput data acquisition, data-driven modeling, and mechanistic modeling to define new mechanisms of immunological disease and to accelerate the translation of these insights into therapies."
Online now: can immunology be mathematically solved? Sealfon&co on the use of mathematical models in the field
Aggregatibacter actinomycetemcomitans–induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis Science Translational Medecine 14 Dec 2016:
"Connecting the mouth microbiome and rheumatoid arthritis" Eric Topol
Creation of a Kinase On/Off Switch GEN News Highlights December 14, 2016
"Researchers report a new technique that switches protein kinases on and off"
If You Take Ibuprofen Often, Read This TIME Dec. 14, 2016
"A new study finds a link between over-the-counter painkillers and hearing loss among women"
Repeated anesthesia exposure could hurt young brains, FDA warns STAT December 14, 2016
The Current State of Epigenetic Research in Humans: Promise and Reality JAMA Pediatrics December 05, 2016
"The lack of a clear, agreed definition means the term epigenetic is now used to describe many processes associated with the control of gene expression, including DNA methylation, histone modifications, and noncoding RNA, despite the fact that we do not know of biochemical mechanisms allowing histone modifications or noncoding RNA to be “heritable” from parent to daughter cell through mitosis or meiosis."
Imagining the future of bioimage analysis Nature Biotechnology 2016
"Here, we summarize the current state of the art in bioimage analysis and provide a perspective on likely future developments."
"The future of biologic imaging analysis (w/ use of AI)" Eric Topol
Is Sugar Killing Us? The Wall Street Journal Dec. 9, 2016
RNA Modification Helps Drosophila Straighten Up and Fly Right GEN News Highlights December 9, 2016
"m6A RNA modification plays important role in fine-tuning determination of male or female"
People susceptible to the placebo effect may be keeping us from getting new drugs The Washington Post Dec 2, 2016
"Could knowing the genomics of placebo response change the way we do clinical trials?" Eric Topol
Associations Between Blood Pressure and Outcomes Among Blacks in the Jackson Heart Study Journal of the American Heart Association December 7, 2016
"Even modest blood pressure elevation linked to mortality, heart failure" Eric Topol
Unravelling the potential of nucleic-acid-based drugs BioPharma Dealmakers Nov 23, 2016
"Visualizing recent deal-making for nucleic-acid-based drugs" Nature Rev Drug Disc
Four New Names Officially Added to the Periodic Table of Elements The New York Times Science DEC. 1, 2016
"Please welcome to the periodic table: Nihonium, Moscovium, Tennessine and Oganesson."
Gamma frequency entrainment attenuates amyloid load and modifies microglia Nature 07 December 2016
"Our findings uncover a previously unappreciated function of gamma rhythms in recruiting both neuronal and glial responses to attenuate Alzheimer’s-disease-associated pathology."
Scientists discover way of developing test for Parkinson's disease diagnosis MedicalXpress December 7, 2016
"Misfolded proteins associated with Parkinson's disease were detected in cerebrospinal fluid by scientists at McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth), paving the way to development of a biochemical test to diagnosis the disease."
More information: Mohammad Shahnawaz et al, Development of a Biochemical Diagnosis of Parkinson Disease by Detection of α-Synuclein Misfolded Aggregates in Cerebrospinal Fluid, JAMA Neurology (2016). DOI: 10.1001/jamaneurol.2016.4547
New study indicates weekly consumption of chocolate lowers the risk for diabetes MedicalXpress December 7, 2016
"New research from the Maine-Syracuse Longitudinal Study (MSLS) confirms that persons who eat chocolate at least once a week have a lower prevalence of diabetes and are at lower risk for a diagnosis of diabetes four to five years later."
More information: Georgina E. Crichton et al. Habitual chocolate intake and type 2 diabetes mellitus in the Maine-Syracuse Longitudinal Study: (1975–2010): Prospective observations, Appetite (2017). DOI: 10.1016/j.appet.2016.10.008
A comprehensive map of molecular drug targets Nature Reviews Drug Discovery 2016
"Here, we present an updated comprehensive map of molecular targets of approved drugs. We curate a total of 893 human and pathogen-derived biomolecules through which 1,578 US FDA-approved drugs act."
"Discovery of de-regulation of RNA splicing as a driver of aging" Eric Topol
"Genomics of personality" Eric Topol
Is addiction a “brain disease”? Harvard Health Publications March 11, 2016
"The biology behind addiction & recovery shows it goes beyond "just say no"
"The New England Journal of Medicine recently published a review of the “brain science” related to addiction and its management by Dr. Nora Volkow and her colleagues. It is a great review with terrific graphics. I’ve sent it to several of my colleagues."
"A newborn state-of-the-art genomic workup w/ fascinating unraveling of his diagnosis" Eric Topol
Therapies: Progressive steps Nature 2016
"Progress in therapy for progressive multiple sclerosis… nice review by @ElieDolgin" Eric Topol
Enhanced CRISPR allows exploration of disease in every cell type Drug Target Review Dec 2, 2016
"Wellcome Trust Sanger Institute and University of Cambridge researchers have created sOPTiKO, a more efficient and controllable CRISPR genome editing platform."
"Who would have thought there might be a connection btwn Parkinsons & the gut microbiome?" Eric Topol
Key cause of Parkinson's disease can be treated MedicalXpress December 1, 2016
"We found that a particular toll-like receptor, TLR2, is increased in neurons in post-mortem PD brain tissue, which provided new information for us. Given that neurons accumulate α-synuclein in Parkinson's disease, our results suggest that TLR2 is of central importance in understanding how the disease starts."
"Crucially, the team also introduced a drug that inhibited TLR2, which prevented the increase of α-synuclein 'clumping' in the stem cell-derived neurons, suggesting it is a target for further research into therapeutic interventions."
More information: Nicolas Dzamko et al. Toll-like receptor 2 is increased in neurons in Parkinson's disease brain and may contribute to alpha-synuclein pathology, Acta Neuropathologica (2016). DOI: 10.1007/s00401-016-1648-8
Psychologists discover brain connections in people with autism show more symmetry between hemispheres MedicalXpress December 1, 2016
"MRI (magnetic resonance imaging) scans revealed that connections between white matter in the brains of young people with autism were more symmetrical across hemispheres."
"More information: Ruth A. Carper et al. Reduced Hemispheric Asymmetry of White Matter Microstructure in Autism Spectrum Disorder, Journal of the American Academy of Child & Adolescent Psychiatry (2016). DOI: 10.1016/j.jaac.2016.09.491"
Solving mysteries of how water works Phys Org December 1, 2016
"More information: Conrad T. Wolke et al. Isotopomer-selective spectra of a single intact H2O molecule in the Cs+(D2O)5H2O isotopologue: Going beyond pattern recognition to harvest the structural information encoded in vibrational spectra, The Journal of Chemical Physics (2016). DOI: 10.1063/1.4941285"
Surprising monkey study could lead to 'functional' HIV cure Reuters Health News Dec 1, 2016
"Last month, Michael and researchers at Harvard's Beth Israel Deaconess Medical Center published the results of a monkey test of Johnson & Johnson's HIV vaccine candidate called Ad26/MVA and Gilead's experimental drug GS-986.
On its own, the vaccine had a modest effect. But it was even more effective when it was given with GS-986, a so-called TLR-7 agonist that “kicks the immune system up to a higher gear,” Michael said."
Virus-inspired delivery system transfers microscopic cargo between human cells Phys Org November 30, 2016
"Nanocages are part of a virus-inspired system for delivering small molecules to cells. The self-assembling cages are built from proteins, also represented as a ribbon structure"
More information: Jörg Votteler et al, Designed proteins induce the formation of nanocage-containing extracellular vesicles, Nature (2016). DOI: 10.1038/nature20607
PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study The Lancet Diabetes & Endocrinology 2016
"Genomics: Less LDL cholesterol & more diabetes risk" Eric topol
"These data provide insights into potential adverse effects of LDL-C-lowering therapy."
Learning makes animals intelligent Phys Org November 30, 2016
"The fact that animals can use tools, have self-control and certain expectations of life can be explained with the help of a new learning model for animal behaviour. Researchers at Stockholm University and Brooklyn College have combined knowledge from the fields of artificial intelligence, ethology and the psychology of learning to solve several problems concerning the behaviour and intelligence of animals."
More information: The power of associative learning and the ontogeny of optimal behavior, Royal Society Open Science, rsos.royalsocietypublishing.org/lookup/doi/10.1098/rsos.160734
Smoking boosts heart attack risk 8-fold for younger adults Reuters Health Nov 29, 2016
"The increased risk among smokers likely arises because smoking affects the plasticity of arteries and what happens inside them, said Dr. Umesh Khot, who is vice chair of cardiovascular medicine at the Cleveland Clinic in Ohio."
This is your brain on God: Spiritual experiences activate brain reward circuits MedicalXpress November 29, 2016
"Religious and spiritual experiences activate the brain reward circuits in much the same way as love, sex, gambling, drugs and music, report researchers at the University of Utah School of Medicine. The findings will be published Nov. 29 in the journal Social Neuroscience."
More information: Michael A. Ferguson et al, Reward, salience, and attentional networks are activated by religious experience in devout Mormons, Social Neuroscience (2016). DOI: 10.1080/17470919.2016.1257437
Hybrid approach predicts and confirms structure of complex metal nanoparticles Phys Org November 29, 2016
More information: B. E. Conn et al. Confirmation of a de novo structure prediction for an atomically precise monolayer-coated silver nanoparticle, Science Advances (2016). DOI: 10.1126/sciadv.1601609
Aβ Amyloid Pathology Affects the Hearts of Patients With Alzheimer’s Disease J Am Coll Cardiol. 2016
"Here, the authors provide the first report of the presence of compromised myocardial function and intramyocardial deposits of Aβ in AD patients. The findings depict a novel biological framework in which AD may be viewed either as a systemic disease or as a metastatic disorder leading to heart, and possibly multiorgan failure."
"A study implicating β-amyloid in Alzheimers can cause infiltrative heart muscle dysfunction"Eric Topol
Generation of genome-scale metabolic reconstructions for 773 members of the human gut microbiota Nature Biotechnology 2016
Engineers develop first-ever capsule to treat hemophilia MedicalXpress November 28, 2016
"In the near future, hemophiliacs could be able to treat their disease by simply swallowing a capsule." "The researchers describe their system in the Nov. 30 issue of the International Journal of Pharmaceutics"
Scientists create reagents to simplify production of fine chemicals and pharmaceuticals Phys Org November 28, 2016
More information: Rapid heteroatom transfer to arylmetals utilizing multifunctional reagent scaffolds, Nature Chemistry, nature.com/articles/doi:10.1038/nchem.2672
Anti-inflammatory medications and the risk for cardiovascular disease: A new study, a new perspective Harvard Health Publications November 23, 2016
"The results of the PRECISION (Prospective Randomized Evaluation of Celecoxib Integrated Safety versus Ibuprofen or Naproxen) trial were released. And the news is good for celecoxib." Robert H. Shmerling, MD, Faculty Editor, Harvard Health Publications
See: Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis NEJM November 13, 2016
Rogue protein's partners offer hope in Parkinson's disease Science 25 Nov 2016
"Last week, findings presented at the huge annual meeting of the Society for Neuroscience further buttressed the theory that spread of the rogue protein, called α-synuclein, is responsible for the progressive disease, which is marked by tremor, stiff movements, depression, and, ultimately, dementia"
"Progress in Parkinsons: biology of the rogue protein and its partners" Eric Topol
"A small RNA with potentially a big brain effect" Eric Topol
Eli Lilly’s Alzheimer’s Antibody Does Not Work Science Translational Medicine November 23, 2016
Derek Lowe's commentary on drug discovery and the pharma industry. An editorially independent blog from the publishers of Science Translational Medicine.
Failed Alzheimer’s trial does not kill leading theory of disease Nature 23 November 2016
"The drug, and others based on the ‘amyloid hypothesis’, are still being tested in other, different trials."
New atlas depicts first two months of human development in 3-D MedicalXpress November 25, 2016
More information: B. S. de Bakker et al. An interactive three-dimensional digital atlas and quantitative database of human development, Science (2016). DOI: 10.1126/science.aag0053
"The test measures blood concentrations of plasma ceramides, a class of lipids that are highly linked to cardiovascular disease processes."
"MML collaborated on the test with Zora Biosciences Oy, a diagnostics discovery company based in Finland that specializes in cardiovascular disease."
Diagnosis of multiple sclerosis: progress and challenges The Lancet 23 November 2016
"A tour de force on multiple sclerosis: 3 review series" Eric Topol
Brain mechanisms in drug addiction—new brain pathways revealed MedicalXpress November 24, 2016
"UNSW researchers have identified two distinct brain pathways that are switched on during alcohol-related relapse. The discovery opens up a new target for developing treatments for drug and alcohol addiction."
See: A. A. Prasad et al. Ventral Pallidum Output Pathways in Context-Induced Reinstatement of Alcohol Seeking, Journal of Neuroscience (2016)
Circadian time signatures of fitness and disease Science 25 Nov 2016
"An exceptional review of circadian rhythm in health and disease" Eric Topol
"A wearable, printable multifunctional sensor for ECG, UV exposure, temp, 3-axis motion" Eric Topol
"Inclisiran (ALN-PCSsc) is a long-acting RNA interference (RNAi) therapeutic agent that inhibits the synthesis of proprotein convertase subtilisin–kexin type 9 (PCSK9), a target for the lowering of low-density lipoprotein (LDL) cholesterol."
First steps to neutralizing Zika: How highly potent antibody neutralizes Zika infection discovered MedicalXpress November 24, 2016
"Previously, C10 was identified as one of the most potent antibodies able to neutralise Zika infection. Now, Associate Prof Lok Shee-Mei and her team at the Emerging Infectious Disease Programme of Duke-NUS have taken it one step further by determining how C10 is able to prevent Zika infection."
Neutralization mechanism of a highly potent antibody against Zika virus Nature Communications 2016
Use of genetic algorithm helping to find the best carbon dioxide sponge Phy Org November 24, 2016
See: S. P. Collins et al. Materials design by evolutionary optimization of functional groups in metal-organic frameworks, Science Advances (2016)
Hope for anti-amyloid antibodies surges, yet again Nature Biotechnology 2016
Alzheimer: Lilly Announces Top-Line Results of Solanezumab Phase 3 Clinical Trial Lilly 2016
"INDIANAPOLIS, Nov. 23, 2016 /CNW/ -- Eli Lilly and Company (NYSE: LLY) today announced that solanezumab did not meet the primary endpoint in the EXPEDITION3 clinical trial, a phase 3 study of solanezumab in people with mild dementia due to Alzheimer's disease (AD)."
"The researchers, from the University of Cambridge, have studied how a phenomenon called hydrophobicity (lack of affinity for water) in the proteins amyloid-beta and alpha synuclein—which are associated with Alzheimer's and Parkinson's respectively - changes as they stick together."
Microcephaly Found in Babies of Zika-Infected Mothers Months After Birth The New York Times NOV. 22, 2016
Genetics Startup wants To Create A World Of Personalized From Your DNA fastcompany.com 11.21.16
"As the price of DNA sequencing drops, a new wave of consumer genomics companies is taking the science mainstream. Are you ready?"
Our brains have a basic algorithm that enables our intelligence, scientists say MedicalXpress November 21, 2016
"We present evidence that the brain may operate on an amazingly simple mathematical logic."
Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects Nature Genetics 2016
"A recurrent theme: importance of copy number variants in schizophrenia" Eric Topol
Mitochondrial Matchmaking NEJM 2016
"Mitochondrial Matchmaking: A Mouse with Genomes from Two Different Strains"
Scientists successfully create blood from skin cells MedicalXpress November 21, 2016
"Researchers in Singapore have artificially generated new mouse blood and immune cells from skin cells. This is a significant first step towards the eventual goal: the engineering of new human blood cells from skin cells or other artificial sources."
""This is not only of practical importance for regenerative medicine in terms of potentially yielding a source of new blood or immune cells, but it is also interesting from a fundamental biological perspective that two very different cells - like skin and blood - can be interconverted," added Dr Kyle Loh"
Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors Nature Communications 2016
"We've long known damaged heart tissue can turn into bone, but how? Now there's a mechanism" Eric Topol
Their brains had the telltale signs of Alzheimer’s. So why did they still have nimble minds? STAT November 14, 2016
"The defective proteins that are widely thought to kill brain neurons and cause, or at least indicate, Alzheimer’s disease1 do not always have that calamitous result, scientists reported on Monday, raising more doubts about conventional approaches to diagnosing and finding treatments2 for Alzheimer’s."
See: Changiz Geula et al. Northwestern University Feinberg School of Medicine
"CD4bs antibody N6 potently neutralizes 98% of HIV isolates"
SnapShot: Epigenomic Assays CELL 17 November 2016
"Creative epigenomics cover @CellCellPress on blueprint IHEC project & summary of key assays" Eric Topol
Synthetic biology pulls CO2 out of the atmosphere CEN November 21, 2016
"A suite of enzymes borrowed from humans, plants, and other life-forms can turn the greenhouse gas into industrial building block chemicals"
Take a journey into the center of a cell STAT November 18, 2016
"The researchers used a powerful X-ray microscope to snap pictures of stem cells at different stages of differentiation. They repeated those snapshots from dozens of different angles at every stage, compiling those images to come up with a 3-D reconstruction of the cell as it changes."
Hi-tech skin patch might someday track your health MedicalXpress November 18, 2016
"A new type of acoustic sensor that resembles a small Band-Aid on the skin can monitor your heartbeat and other health measures, researchers say."
Y. Liu et al. Epidermal mechano-acoustic sensing electronics for cardiovascular diagnostics and human-machine interfaces, Science Advances (2016).
The Art of the Chemical Bond
The Future of Prebiotic Chemistry
Two recent papers reporting advances in our understanding of how a protometabolism may have developed in a prebiotic world add new meaning to the theme “First Reactions” and highlight the challenges facing synthetic organic chemists attempting to retrodict the origins of life ACS Cent. Sci. 2016
"A worldwide assessment of blood pressure over 40 years… and shifting geo-patterns" Eric Topol
Biocompatible heterogeneous copper catalyst for click chemistry in living organisms Phys Org November 15, 2016
"Assembling a drug from harmless components at the target location, such as a tumor, would help reduce the side effects of treatment. In the journal Angewandte Chemie, British and Malaysian scientists present a new, nontoxic catalyst made of copper nanoparticles that can be used to specifically and selectively assemble building blocks in a living system. It was shown to be possible to make an anti-tumor drug from two benign components in situ."
Copper Catalysis in Living Systems and In Situ Drug Synthesis, Angewandte Chemie 2016
Team makes strides in fight against Zika MedicalXpress November 15, 2016
"The paper appears in the Proceedings of the National Academy of Sciences."
"The mystery has been how these viruses get around the insect's immune response, and the answer is the virus makes a protein that suppresses the immune response, Myles said."
Yellow fever virus capsid protein is a potent suppressor of RNA silencing that binds double-stranded RNA, PNAS, 2016
Scientists successfully grow working minilungs from stem cells FierceBiotech Nov 14, 2016
"In just eight weeks, the resulting transplanted tissue had impressive tube-shaped airway structures similar to the adult lung airways,” said Briana Dye, a graduate student in the university’s department of cell and developmental biology and the lead author of the study, which was published in the journal eLife."
Study: 'Vocal biomarkers' can predict likelihood of heart disease FierceBiotech Nov 14, 2016
"Voice analysis specialist Beyond Verbal and Mayo Clinic unveiled results from a new study demonstrating a strong correlation between some voice characteristics and the presence of coronary artery disease (CAD)."
Two chemicals boost cardiac regeneration in mice with heart failure FierceBiotech Nov 10, 2016
"Gladstone Institute scientists have pinpointed two chemicals that help the heart convert scar tissue into healthy cardiac muscle. The discovery could lead to new treatments for heart failure, for which there is no cure."
A step toward biodegradable plastics MIT NEWS November 11, 2016
"MIT chemists have determined the structure of a bacterial enzyme that can produce biodegradable plastics, an advance that could help chemical engineers tweak the enzyme to make it even more industrially useful."
Ageing, neurodegeneration and brain rejuvenation Nature 09 November 2016
"As we age, our brain is steadily deteriorating :-( Can it be prevented? A nice OA review" Eric Topol
Faster parallel computing MIT NEWS September 13, 2016
"Researchers have designed a new programming language that lets application developers manage memory more efficiently in programs that deal with scattered data points in large data sets. In tests on several common algorithms, programs written in the new language were four times as fast as those written in existing languages."
Increasing the neurological-disease toolbox using PSC-derived microglia Nature Medecine 2016
"A new study presents a protocol to differentiate human induced pluripotent stem cells (iPSCs) into microglia that closely resemble their in vivo counterparts. These cells offer an exciting new tool for learning more about the role of microglia in disease.
Slow motion waves of jumping genes in the humangenome Phys Org November 14, 2016
"The findings, published in Physical Review Letters by physicists Chi Xue and Nigel Goldenfeld, are an important step toward understanding the complex ways that genomes change over the lifetime of individual organisms, and how they evolve over generations."
The Lancet Countdown: tracking progress on health and climate change The Lancer 14 November 2016, 2016
"The health impacts of climate change"
"the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has granted a positive opinion for HUMIRA® (adalimumab) for the treatment of active moderate to severe hidradenitis suppurativa (HS) in adolescents from 12 years of age with an inadequate response to conventional systemic HS therapy. If approved, HUMIRA will become the first and only biologic treatment option for patients 12 years of age and older. HUMIRA was approved for adults with moderate to severe HS by the European Commission in July 2015."
How to defeat dementia Nature 09 November 2016
"Three things are needed to turn the tide on the costliest crisis in health care."
"How to defeat dementia… we don't know yet, but very good update" Eric Topol
Creating a Functional Cure for HIV GEN Highlights November 10, 2016
"Investigators found that administering vaccine plus immune stimulant reduced hard-to-reach reservoirs of HIV-like virus in animal model"
Un antidiabétique contre le vieillissement Le Figaro 11/11/2016
"La metformine pourrait contrer la production d’une protéine toxique à l’œuvre dans la progeria, une maladie rare."
Metformin decreases progerin expression and alleviates pathological defects of Hutchinson–Gilford progeria syndrome cells npj Aging and Mechanisms of Disease 2016
"Overall, these results suggest a novel approach towards therapeutics for HGPS that can be added to the currently assayed treatments that target other molecular defects associated with the disease."
Roche announces positive results for Actemra in phase III study Reuters November 13
"Swiss drugmaker Roche said on Sunday its rheumatoid arthritis medication Actemra for giant cell arteritis showed to be superior to steroids alone in maintaining steroid-free remission in a Phase III study."
Antibody suppresses HIV in infected individuals MedicalXpress November 10, 2016
"The administration of VRC01, a potent and broadly neutralizing HIV-specific antibody, is safe, is well-tolerated, generated high plasma concentrations and modestly delayed the return of HIV viral rebound in HIV-1 infected individuals after they stopped receiving antiretroviral therapy, according to a study published in the New England Journal of Medicine by researchers at the University of Alabama at Birmingham, the National Institutes of Health and the University of Pennsylvania Penn Center for AIDS Research."
"VRC01 slightly delayed plasma viral rebound in the trial participants, as compared with historical controls, but it did not maintain viral suppression by week 8. In the small number of participants enrolled in these trials, no safety concerns were identified with passive immunization with a single bNAb (VRC01). "
HIV test performed on USB stick Drug Target Review 10 November 2016
"The device, created by scientists at Imperial College London and DNA Electronics, uses a drop of blood to detect HIV, and then creates an electrical signal that can be read by a computer, laptop or handheld device."
"Visiondirect_UK have launched a interactive tool which lets you see through the eyes of someone with vision issues"
"You can use this tool to see through the eyes of someone who has problems with their vision and learn more about what can cause these issues."
Functional textiles clean pollutants from air and water Phys Org November 10, 2016
Cup-shaped beta-cyclodextrin polymers are infused into fabric during the polymerization process, giving the fabric the ability to sequester pollutants in both water "and air"
"The implantable components integrated in the brain–spine interface have all been approved for investigational applications in similar human research, suggesting a practical translational pathway for proof-of-concept studies in people with spinal cord injury."
Paralyzed monkeys regain control of their legs after brain implants CNN November 9, 2016
"Researchers at the École polytechnique fédérale de Lausanne (EPFL) in Switzerland were able to restore movement in the legs of two paralyzed rhesus macaques within two weeks of them being injured; one regained mobility after just six days."
"this new research in monkeys is the first to record brain activity and link this to nerves within the spinal cord itself. "The brain is in control," Courtine said."
The origin and evolution of cell types Nature Reviews Genetics 2016
"How cells grow up (quite a review) in a big year for the cell atlas" Eric Topol
"The next generation of fetal sequencing/ non-invasive prenatal testing" Eric Topol
New antibody cuts mother-to-fetus Zika transmission in mice FierceBiotech Nov 8, 2016
"Researchers from Vanderbilt University, Washington University in St. Louis and Philadelphia-based Integral Biotech isolated antibody-secreting white blood cells of three people who had previously had a Zika infection. They generated antibodies from these cells and found that one, dubbed ZIKV-117, neutralized every Zika virus strain they tested"
"We evaluated the therapeutic efficacy of ZIKV-117 in pregnant and non-pregnant mice. mAb treatment markedly reduced tissue pathology, placental and fetal infection, and mortality in mice."
"These findings demonstrate the first rationally discovered molecule targeting specific neural circuitries for therapeutic advantage"
"A new study shows LY3130481 prevents multiple seizure types in rats and mice and without motor side effects"
"Another positive step towards genome editing cure of SickleCell disease" Eric Topol
Scaling probabilistic models of genetic variation to millions of humans Nature Genetics 2016
"We demonstrate that TeraStructure performs as well as existing methods on current globally sampled data, and we show using simulations that TeraStructure continues to be accurate and is the only method that can scale to tera-sample sizes."
"Machine learning for massive genomic datasets" Eric Topol
New Computational Tool May Speed Drug Discovery CheckOrphan November 04, 2016
"The creation of fABMACS is a significant step toward robust virtual drug discovery because it saves time and money. It allows us to better harness the power of existing software while greatly improving our ability to predict the way that a potential drug interacts with a protein."
Study challenges model of Alzheimer's disease progression MedicalXpress November 4, 2016
Taylor W. Schmitz et al, Basal forebrain degeneration precedes and predicts the cortical spread of Alzheimer's pathology, Nature Communications (2016).
Making computers explain themselves MIT October 27, 2016
New training technique would reveal the basis for machine-learning systems’ decisions
One brain, many genomes Science 04 Nov 2016
"Every cell in an individual actually has a unique genome, an imperfect copy of its cellular ancestor differentiated by inevitable somatic mutations arising from errors in DNA replication and other mutagenic forces."
"One brain and many genomes—mosaicism is much bigger than we imagined" Eric Topol
See the first color images produced by an electron microscope Science Nov. 3, 2016
"New: the 1st color images made by electron microscopy" Eric Topol
Are You Ready to Swallow a Pill Poop? WIRED 2016
"Fecal transplants may be a miracle cure for some of our natiest illnesses"
Unusual Base-Pairing Interactions in Monomer–Template Complexes ACS Cent. Sci.2016
"Watson Crick may not have been the only base pairing motif in prebiotic conditions"
"High-resolution crystal structures show that the binding of nucleotide monomers to RNA templates occurs not only through the expected Watson-Crick base pairing but also through a variety of unexpected noncanonical base-pairing interactions."
"The central nervous system and the gut microbiome a great review" Eric Topol
Phase II and phase III failures: 2013–2015 Nature Reviews Drug Discovery 2016
"Understanding the reasons for clinical failure is essential for decreasing attrition in clinical development. With this in mind, we examined the reported causes of drug candidate attrition by clinical development phase and by therapeutic area for the period 2013−2015 (Drugs Today 52, 131–163; 2016)."
Light drives single-molecule 3-wheelers Phys Org November 4, 2016
"Scientists at Rice University and at the University of Graz, Austria, are driving three-wheeled, single-molecule "nanoroadsters" with light and, for the first time, seeing how they move."
Scientists find key protein for spinal cord repair MedicalXpress November 3, 2016
Adult zebrafish are capable of regenerating their spinal cords after a complete severing injury. This close-up of the cells involved reveals supporting glial cells are first to cross the gap between the severed ends. Neuronal cellsoon follow. Duke Regeneration Next researchers discovered that a protein in the glia called connective tissue growth factor, or CTGF, is crucial for this process.
WHO recommends 29 ways to stop surgical infections and avoid superbugs WHO 3 November 2016
"L'OMS recommande 29 moyens de mettre fin aux infections en chirurgie et d’éviter les superbactéries"
Two Essential Sleep and Dreaming Genes Identified GEN News Highlights November 3, 2016
The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer’s disease patients Science Translational Medicine 02 Nov 2016
"The discovery of BACE1 inhibitors that reduce β-amyloid peptides in Alzheimer’s disease (AD) patients has been an encouraging development in the quest for a disease-modifying therapy. Kennedy and colleagues now report the discovery of verubecestat, a structurally unique, orally bioavailable small molecule that potently inhibits brain BACE1 activity resulting in a reduction in Aβ peptides in the cerebrospinal fluid of animals, healthy volunteers, and AD patients."
Researchers report promising new Alzheimer's drug Phys Org November 3, 2016
"The treatment uses a compound called verubecestat, developed by US pharmaceutical firm. It reduces levels of proteins called beta amyloids by blocking an enzyme known as BACE1."
Earlier Alzheimer's diagnosis may be possible with new imaging compound MedicalXpress November 2, 2016
"Fluselenamyl is both more sensitive and likely more specific than current agents," said Vijay Sharma, PhD, a professor of radiology, of neurology and of biomedical engineering, and the study's senior author. "Using this compound, I think we can reduce false negatives, potentially do a better job of identifying people in the earliest stages of Alzheimer's disease and assess the effects of treatments."
Small-RNA Sequencing of Single Cells GEN News Highlights November 2, 2016
"A new method has allowed researchers to map the presence of short RNA sequences in an individual cell."
Stem cells from schizophrenics produce fewer neurons theguardian 1 nov, 2016
"New research shows that a genetic mutation associated with schizophrenia alters the process of cellular differentiation, disturbing the balance of neurons and glia in the brain"
Supercomputers capture the crush in biological cells Phys Org November 2, 2016
"the research team was able to conduct computer simulations that model the cellular interior of a bacterium, and show a detailed view of how the various molecular components interact in a very dense environment."
Isseki Yu et al. Biomolecular interactions modulate macromolecular structure and dynamics in atomistic model of a bacterial cytoplasm, eLife (2016)
On the origin of life: Studying how the first biomolecule self-replicated Phys Org November 2, 2016
Wen Zhang et al. Unusual Base-Pairing Interactions in Monomer–Template Complexes, ACS Central Science (2016)
Carbon-carbon bond formation at selective aliphatic carbon sites Phys Org November 2, 2016
"John C. K. Chu and Tomislav Rovis of Colorado State University and Columbia University have devised a strategy for C-C bond formation at inert tertiary C-H bonds of amides. This reaction involves cleavage of the C-H bond and subsequent coupling with an alkene. Their reaction works with a variety of amides and alkenes and is selective for a particular C-H among all seemingly indistinguishable C-H bonds. Their report appears in Nature."
"Reminder for not being too aggressive w/ blood pressure lowering in those w/coronary disease" Eric Topol
Senescent intimal foam cells are deleterious at all stages of atherosclerosis Science 28 Oct 2016
"Together, these results demonstrate that senescent cells are key drivers of atheroma formation and maturation and suggest that selective clearance of these cells by senolytic agents holds promise for the treatment of atherosclerosis."
Commonly prescribed medicines no more effective than placebo for pediatric migraines MedicalXpress October 27, 2016
"A study to be published Oct. 27 in The New England Journal of Medicine shows no significant differences among amitriptyline, topiramate and placebo in reducing headache days or related disability"
The gut microbiome—an emerging complex trait Nature Genetics 2016
"The complex gut microbiome: nice synthesis of 3 new studies" Eric Topol
Engineering a cardiac stem cell therapy inspired by the body itself MedicalXpress October 27, 2016
New research suggests the brain can learn to "see" again after years of blindness CBS NEWS October 27, 2016
'Neighbor maps' reveal the genome's 3-D shape Phys Org 2016
"A group coordinated by SISSA Trieste has built a 3-D computer model of the human genome. The shape of DNA (and its sequence) affects biological processes and is crucial for understanding its function. The study has provided an approximate but realistic 3-D identikit of the human genome. The resulting structural reconstruction, based on experimental information and statistical methods, will be refined as new experimental data become available. The study is published in Scientific Reports."
The neural basis of perceived intensity in natural and artificial touch Science Translational Medicine 26 Oct 2016
"Human vs. machine based touch: understanding the neural basis" Eric Topol
Natural compound reduces signs of aging in healthy mice MedicalXpress October 27, 2016
"Now, scientists at Washington University School of Medicine in St. Louis have shown that supplementing healthy mice with a natural compound called NMN can compensate for this loss of energy production, reducing typical signs of aging such as gradual weight gain, loss of insulin sensitivity and declines in physical activity."
NMN (nicotinamide mononucleotide)
Fruity with a hint of double helix: A startup claims to tailor wine to your DNA STAT October 27, 2016
"A new wine delivery service called Vinome1 is promising to deliver “the ultimate personalized wine experience” — customized to your DNA."
Study finds non-invasive method that may help speed relief from depression MedicalXpress October 27, 2016
"UCLA researchers report that a simple biomarker—a pair of brain-wave recordings, or electroencephalograms, that can be performed in a doctor's office in about 10 minutes—can predict whether the person will enter remission after just one week of treatment."
High-dose rifampicin, moxifloxacin, and SQ109 for treating tuberculosis: a multi-arm, multi-stage randomised controlled trial The Lancet Infectious Diseases 26 October 2016
"New online: High-dose rifampicin, moxifloxacin, and SQ109 for treating tuberculosis"
H.I.V. Arrived in the U.S. Long Before ‘Patient Zero’ The New York Times CT. 26, 2016
"Getting the upper hand on the complex regulatory genomic interactions --> heart development" Eric Topol
Yale Scientists Edit Gene Mutations in Inherited Form of Anemia CheckOrphan October 26, 2016
"A Yale-led research team used a new gene editing strategy to correct mutations that cause thalassemia, a form of anemia. Their gene editing technique provided corrections to the mutations and alleviated the disease in mice, the researchers said. The finding could lead to studies of a similar gene therapy to treat people with inherited blood disorders."
In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery Nature Communications 2016
"Successful genome editing of β-thalassemia in experimental model" Eric Topol
Peptide nucleic acids used to edit genes, cure mice of inherited blood disorder GEN News Highlights October 26, 2016
"Triplex-forming PNAs substituted at the γ position plus stimulation of the stem cell factor (SCF)/c-Kit pathway yielded high levels of gene editing in haematopoietic stem cells (HSCs) in a mouse model of human β-thalassaemia,” wrote the authors of the Nature Communications article."
Eyeing a New Way to Diagnose Stroke HOPKINS MEDECINE 2016
"A new bedside exam to more accurately diagnose stroke, via eye movements" Eric Topol
"Parent-led early intervention for autism shows reduction in symptom severity through to ages 7-11 - PACT follow-up"
Researchers use CRISPR to accelerate search for HIV cure MedicalXpress October 25, 2016
"Researchers at UC San Francisco and the academically affiliated Gladstone Institutes have used a newly developed gene-editing system to find gene mutations that make human immune cells resistant to HIV infection."
CRISPR identifies genes that might be targeted to hobble HIV infection STAT October 25, 2016
"They wound up with half a dozen genes (with names like CXCR4, CCR5, LEDGF, and NUP153) whose excision thwarted HIV wholly or partly. The hope is that using genome editing to change one or more such genes in T cells will prevent or vanquish AIDS."
Scientists Uncover Why Hepatitis C Virus Vaccine Has Been Difficult to Make The Scripps Research Institute 2016
"New study suggests that designing a less flexible version of Hep C protein could be key to future vaccine"
Lack of Evidence Linking Calcium With or Without Vitamin D Supplementation to Cardiovascular Disease in Generally Healthy Adults: A Clinical Guideline From the National Osteoporosis Foundation and the American Society for Preventive Cardiology Anale of Internal Medecine 2016
"In light of the evidence available to date, calcium intake from food and supplements that does not exceed the tolerable upper level of intake (defined by the National Academy of Medicine as 2000 to 2500 mg/d ) should be considered safe from a cardiovascular standpoint."
"Calcium intake and heart disease risk: systematic review argues vs risk; -> new guidelines" Eric Topol
Boosting levels of known antioxidant may help resist age-related decline MedicalXpress October 24, 2016
"A new study, published in the journal Redox Biology, also highlighted a compound - N-acetyl-cysteine, or NAC - that is already used in high doses in medical detoxification emergencies. But the researchers said that at much lower levels NAC might help maintain glutathione levels and prevent the routine metabolic declines associated with aging."
"A 3D printed heart-on-a-chip" Eric Topol
"An unexpected finding in transfusion medicine: "old" blood (RBCs) as good as "new" Eric Topol
New bacteria groups, and stunning diversity, discovered underground Phys Org October 24, 2016
"Reconstruction of the genomes of more than 2,500 microbes from sediment and groundwater samples collected at an aquifer in Colorado"
Antibacterial antibodies gain traction - FDA approves antibacterial mAb bezlotoxumab to reduce recurrence of C. difficile infection NATURE REVIEWS DRUG DISCOVERY 2016
"ZINPLAVA (Bezlotoxumab) is indicated to reduce recurrence of Clostridium difficile infection (CDI)"
FDA Approves Merck’s ZINPLAVA™ (bezlotoxumab) to Reduce Recurrence of Clostridium difficile Infection (CDI) in Adult Patients Receiving Antibacterial Drug Treatment for CDI Who Are at High Risk of CDI Recurrence Business Wire October 21, 2016
Chronic Cough NEJM 2016
"The evaluation of chronic cough should address the possibilities of asthma, gastroesophageal reflux disease, and postnasal drip and may require more specialized investigations. For patients with refractory chronic cough, other treatment approaches may be necessary."
"Off pump, on pump heart bypass surgery makes no difference, despite history of off pump push" Eric Topol
Harvard researchers link “good” fats with longer life Harvard Health Publications 2016
"The study found that eating more saturated and trans fats ("bad" fats) was associated with a higher risk of dying during the study period, while eating more polyunsaturated and monounsaturated fats ("good fats") was associated with a lower risk of dying."
"Régime crétois ou méditerranéen, une recette de longévité" : acides gras insaturés = huile d'olive, avocat,.. JAMA Internal Medicine 2016
GILEAD: the anti-fibrotic effect of GS-4997 (selonsertib, Phase II) in patients with NASH after only 24 weeks of treatment ---> Phase III
Studying the Building Blocks of Life in Stereo Sound - The New York Times OCT. 21, 2016
"This is a 3-D model of a folding protein called 1R75. A scientist and a composer worked together to translate the protein’s folding structure into a musical melody that provides a new way to perceive it."
"Turning protein structure into music!"
What Will It Take To Find a Human Pheromone? ACS Cent. Sci., 2016
Quantifying the human proteome Nature Biotechnology 2016
"An atlas of targeted mass spectrometry coordinates provides a starting point for measuring the unmodified human proteome."
Blood molecule key to more efficient batteries YaleNews 2016
"A molecule that transports oxygen in blood could be key to developing the next generation of batteries, and in a way that’s environmentally friendly."
"The Yale lab of Andre Taylor,..., has identified a molecule known as heme that could function as a better catalyst" Nature Commun. Oct 19
Oligodendrocytes selectively myelinate a particular set of axons in the white matter MedicalXpress October 21, 2016
"There are three kinds of glial cells in the brain: oligodendrocytes, astrocytes and microglia. Oligodendrocytes myelinate neuronal axons to increase conduction velocity of neuronal impulses. A Japanese research team at the National Institute for Physiological Sciences (NIPS, Okazaki, Aichi, Japan) has found a characteristic feature of oligodendrocytes that selectively myelinate a particular set of neuronal axons."
ALS study reveals role of RNA-binding proteins and provides new therapeutic target Drug Target Review 2016
"University of California San Diego School of Medicine researchers studied several ALS cases with a mutation in a RNA-binding protein known as hnRNP A2/B1."
"In the study, they describe how damage to this protein contributes to ALS by scrambling crucial cellular messaging systems."
Nouvelles Cibles Thérapeutiques dans le Traitement de la Sclérose Latérale Amyotrophique
Pulmonary effects of immediate versus deferred antiretroviral therapy in HIV-positive individuals: a nested substudy within the multicentre, international, randomised, controlled Strategic Timing of Antiretroviral Treatment (START) trial The Lancet Respiratory Medecine 2016
New study - timing of ART initiation does not affect lung function decline in HIV-positive, ART-naive patients
Automating big-data analysis - With new algorithms, data scientists could accomplish in days what has traditionally taken months. MIT NEWS October 21, 2016
"New algorithms could cut time required for big-data analysis from months to days"
The current state of psychobiotics MedicalXpress October 25, 2016
"Researchers seem to agree that the key players responsible for the bacteria-gut-brain axis—the nervous system of the intestines, the immune system, the vagus nerve, and possibly gut hormones and neurotransmitters (e.g., serotonin and dopamine)—are involved."
FDA awards 21 grants to stimulate product development for rare diseases FDA Release October 17, 2016
A delicate balance between positive and negative emotion MIT News October 17, 2016
"Neuroscientists identify two neuron populations that encode happy or fearful memories. " "Tonegawa is the senior author of the study, which appears in the Oct. 17 issue of Nature Neuroscience. Joshua Kim, an MIT graduate student, is the paper’s lead author."
Immune system plays important role in Duchenne muscular dystrophy, research reveals News Medical Life Science October 14, 2016
New Research Increases Understanding of Duchenne Muscular Dystrophy CheckOrphan October 17, 2016
Association Study of Exon Variants in the NF-κB and TGFβ Pathways Identifies CD40 as a Modifier of Duchenne Muscular Dystrophy The American Journal of Human Genetics October 2016
Neural Networks for the Prediction of Organic Chemistry Reactions ACS Cent. Sci. 2016
‘Artificial brain’ aces undergrad organic chemistry test ChemistryWorld 17 October 2016
"Algorithm learns chemistry just like a human and can predict the outcome of reactions it has never seen before"
Could Gene Therapy Work for Alzheimer’s Disease? GEN News Highlights October 11, 2016
"Researchers at the Imperial College London have just released data from animal studies in which they were able to prevent the development of Alzheimer’s disease (AD) by using a virus to deliver a specific gene into the brain. The results from this study could open avenues toward potential new treatments for the disease."
The drug industry’s answer to opioid addiction: More pills The Washington Post October 16, 2016
"The story of OIC (opioid-induced constipation) illuminates the opportunism of pharmaceutical innovators and the consequences of a heavily drug-dependent society. Six in 10 American adults take prescription drugs, creating a vast market for new meds to treat the side effects of the old ones."
CRISPR/Cas9 Corrects Sickle Cell Mutation GEN News Highlights October 13, 2016
"Using CRISPR/Cas9 to repair the sickle cell mutation in stem cells shows clinical promise. Corrected human cells produce sound hemoglobin and persist when engrafted in a mouse model."
Selection-free genome editing of the sickle mutation in human adult hematopoietic stem/progenitor cells Science Translational Medicine 12 Oct 2016
Organization and function of the 3D genome Nature Reviews Genetics 17, 661-678, 2016
"Understanding how chromatin is organized within the nucleus and how this 3D architecture influences gene regulation, cell fate decisions and evolution are major questions in cell biology."
Masturbation: femmes et hommes se ressemblent de plus en plus Le Figaro 14/10/2016
Finding needles in chemical haystacks Phys Org October 15, 2016
"A team of chemists including Daniel Weix from the University of Rochester has developed a process for identifying new catalysts that will help synthesize drugs more efficiently and more cheaply. The trick was to do something that has not been attempted before, to examine libraries of drugs to find the cure for bad chemistry: new catalysts."
A Google Maps for the Human Body The Atlantic Oct 14, 2016
"A group of scientists has taken the first important steps towards creating the Human Cell Atlas—a complete inventory of our staggeringly diverse cells."
Maladie de Charcot - Paralysé, il écrit par la pensée Le Figaro 14/10/2016
Researchers discover microbes able to convert compounds released from coal directly into methane Phys Org October 14, 2016
"A team of researchers with the National Institute of Advanced Industrial Science and Technology in Japan has discovered the existence of a microbe that is able to convert organic compounds released from coal directly into methane. In their paper published in the journal Science, the team describes the experiments they conducted and the microbes they found."
Robotic - The Recipe for the Perfect Robot Surgeon MIT October 14, 2016
"Alphabet and Johnson & Johnson say dexterous robots equipped with artificial intelligence will make surgeons more productive."
A laboratory in your pocket The Lancet 15 October 2016
A digital medicine essay
Doc Versus Machine - Head-to-head comparison reveals human physicians vastly outperform virtual ones Harvard Medical School October 11, 2016
"The findings, published Oct. 10 in JAMA Internal Medicine, show that physicians’ performance is vastly superior and that doctors make a correct diagnosis more than twice as often as 23 commonly used symptom-checker apps. The analysis is believed to provide the first direct comparison between human-made and computer-based diagnoses."
Le médecin deux fois plus précis que l'algorithme (pour l'instant)
Paralyzed man feels touch through mind-controlled robot hand STAT October 13, 2016
"Tiny chips implanted in Nathan Copeland’s brain are bypassing his broken spinal cord, relaying electrical signals that govern movement and sensation to and from that robotic arm"
Intracortical microstimulation of human somatosensory cortex Science Translational Medicine 19 Oct 2016
"A brain chip restores touch sensation to a young man with tetraplegia" Eric Topol
Researchers obtain first Zika sequence isolated from semen MedicalXpress October 13, 2016
Researchers achieve sustained viral remission in SIV infection MedicalXpress October 13, 2016
"Scientists have shown that they can achieve sustained control of infection by HIV's relative SIV (simian immunodeficiency virus) in rhesus macaques, by supplementing antiretroviral drugs with an antibody (vedolizumab was FDA-approved for the treatment of Crohn's disease and ulcerative colitis in 2014) during and after drug treatment."
Sustained virologic control in SIV+ macaques after antiretroviral and α4β7 antibody therapy Science 14 October 2016
"The drug, vedolizumab, appears to have reduced simian immunodeficiency virus, or SIV, to virtually undetectable levels in infected macaques and kept them there for two years, even after they were taken off of antiretroviral therapy, or ART, said senior author Aftab Ansari."
Un anticorps (vedolizumab) utilisé pour traiter la maladie de Crown pourrait aider à supprimer le VIH (étude sur le singe) Science 2016
Open-heart surgery devices putting patients at risk, CDC warns STAT October 13, 2016
The findings published in the October 11 online issue of Cell Reports.
"Our results further illuminate the complex processes involved in the degradation and decline of neurons, which is, of course, the essential characteristic and cause of AD," said the study's senior author Larry Goldstein, PhD, Distinguished Professor in the Departments of Neuroscience and Cellular and Molecular Medicine at UC San Diego School of Medicine and director of both the UC San Diego Stem Cell Program and Sanford Stem Cell Clinical Center at UC San Diego Health. "But beyond that, they point to a new target and therapy for a condition that currently has no proven treatment or cure."
Novel drugs for depression A new generation of drugs could change the way depression is treated The Economist Oct 15th 2016
"Ketamine’s mode of action is not primarily on monoamines, so the race is on to use what knowledge there is of the way it does work to design a new class of antidepressant. This is a change of direction so radical that some think it heralds a revolution in psychiatry."
Accuracy of Wrist-Worn Heart Rate Monitors JAMA Cardiol. Published online October 12, 2016
How to treat your pain without drugs Time Health Oct. 12, 2016
"6 natural treatments, from acupuncture to pot."
Vitamins A and C help erase cell memory Phys Org October 12, 2016
"Vitamins A and C aren't just good for your health, they affect your DNA too. Researchers at the Babraham Institute and their international collaborators have discovered how vitamins A and C act to modify the epigenetic 'memory' held by cells; insight which is significant for regenerative medicine and our ability to reprogramme cells from one identity to another. The research is published today in Proceedings of the National Academy of Science (PNAS)."
High-Throughput Excipient Discovery Enables Oral Delivery of Poorly Soluble Pharmaceuticals ACS Cent. Sci October 12, 2016
"We identify a polymer discovery paradigm to complement oral drug discovery efforts. Rapid chemistry, screening, and in vitro−in vivo testing of optimal solubilizing polymers can translate otherwise-insoluble drugs into widely-accessible medicines."
New Drug Application for the Treatment of Tardive Dyskinesia has been Accepted for Priority Review by U.S. FDA CheckOrphan October 12, 2016
Tardive dyskinesia:involuntary, repetitive movements of the face, trunk, or extremities, including lip smacking, grimacing, facial movements
Soft robots that mimic human muscles Phys Org October 12, 2016
"An EPFL team is developing soft, flexible and reconfigurable robots. Air-actuated, they behave like human muscles and may be used in physical rehabilitation. They are made of low-cost materials and could easily be produced on a large scale."
Signals from the gut microbiota to distant organs in physiology and disease Nature Medecine October 2016
"In this Review, we will discuss microbiota–host cross-talk and intestinal microbiome signaling to extraintestinal organs. We will review mechanisms of how this communication might contribute to host physiology and discuss how misconfigured signaling might contribute to different diseases."
Orthostatic Hypotension and the Long-Term Risk of Dementia: A Population-Based Study PLOS Medecine October 11, 2016
Molecular Autopsy for Sudden Unexpected Death JAMA October 11, 2016
"A more comprehensive molecular autopsy program, expanded beyond SCD, has the potential to provide more accurate family health information to a wider spectrum of afflicted families. Here we report preliminary results from a systematic, prospective, family-based, molecular autopsy study."
'Poring over' DNA: Advancing nanopore sensing towards lower cost and more accurate DNA sequencing Phys Org October 11, 2016
'Weighing' atoms with electrons Phys Org October 11, 2016
"Problems with a high protein diet" Eric Topol
Should researchers study bunk science? Among respected scientists, a debate ensues STAT October 10, 2016
“A number of the key concepts of homeopathy are not consistent with fundamental concepts of chemistry and physics,”
Alexza granted FDA approval of Adasuve sNDA to treat schizophrenia European Pharmaceutical Review 11 October 2016
"The US Food and Drug Administration (FDA) has approved Alexza Pharmaceuticals supplemental new drug application (sNDA) which sought certain changes in the product label and modifications to the risk evaluation mitigation strategy (REMS) program for Adasuve (loxapine) inhalation powder, the first and only orally inhaled medicine to treat agitation associated with schizophrenia or bipolar I disorder in adults."
First of our three billion heartbeats is sooner than we thought MedicalXpress October 11, 2016
"This study describes some of the very first stages in the development of a beating heart, identifies some of the key molecules involved"
Envelope-specific antibodies and antibody-derived molecules for treating and curing HIV infection Nature Reviews Drug Discovery 2016
"Here, we review these immunotherapies, which are designed with the goal of curing HIV-1 infection."
Novel immunotherapies: bispecific dual-affinity re-targeting (DART) molecules & other bi- & trispecific antibody designs that can recognize HIV-1
Roche: statut prioritaire pour : Lucentis® (ranibizumab injection) for Wet AMD, DME & RVO
Roche a annoncé mardi que la FDA avait accordé un statut prioritaire à sa demande d'enregistrement concernant le Lucentis dans le traitement de la néovascularisation choroïdienne, une dégénérescence myopique
As DNA reveals its secrets, scientists are assembling a new picture of humanity STAT October 7, 2016
"Scientists are working on creating genome graphs to develop a better understanding of how our DNA influences our lives."
Going beyond imaging amyloid in Alzheimer’s disease Nature Medecine October 2016
"New PET tracers for non-amyloid targets are opening up possibilities for #Alzheimer's disease research."
Epigenetic inheritance of acquired traits through sperm RNAs and sperm RNA modifications Nature Reviews Genetics 2016
"We discuss the possible mechanisms by which sperm become acquisitive following environmental–somatic–germline interactions, and how they transmit paternally acquired phenotypes by shaping early embryonic development."
"A new appreciation for the importance of sperm RNAs— a very provocative review" Eric Topol
"Héritage épigénétique : ce qu’a vécu votre père influe sur votre vie"
"We highlight some of the emerging principles on the role of dense regulatory circuitry, epigenetic memory, cell type fluidity, and reuse of regulatory modules in achieving and maintaining appropriate responses to a changing environment. These provide a first step toward a systematic understanding of molecular circuits in complex tissues."
"Immunomics: how new tools are markedly enhancing our understanding of the "tissue circuit" Eric Topol
Une Française contrainte d'aller aux États-Unis pour une greffe des deux mains Le Figaro le 06/10/2016
Signals from the gut microbiota to distant organs in physiology and disease Nature Medicine 22, 1079–1089, 2016
"In this Review, we will discuss microbiota–host cross-talk and intestinal microbiome signaling to extraintestinal organs. We will review mechanisms of how this communication might contribute to host physiology and discuss how misconfigured signaling might contribute to different diseases."
"The gut microbiome talks to every body - a wonderful review" Eric Topol
"Non-DNA transgenerational inheritance—epigenetics—has "major implications for human health"" Eric Topol
Birefringence microscopy platform for assessing airway smooth muscle structure and function in vivo Science Translational Medicine 05 Oct 2016
Mechanistic modeling of hemoglobin glycation and red blood cell kinetics enables personalized diabetes monitoring Science Translational Medicine 05 Oct 2016
Scientists devise a more accurate way to gauge blood sugar averages in diabetes MedicalXpress October 5, 2016
Mitochondrial Mobility and Neuronal Recovery N Engl J Med 2016, 1295-1296
"A recent study of in vitro and in vivo axonal regeneration underscores the importance of having competent mitochondria at the site of axonal injury."
De novo assembly and phasing of a Korean human genome Nature 538, 243-247, 2016
Brain study reveals how teens learn differently than adults MedicalXpress October 5, 2016
Evidence for a limit to human lifespan Nature 538, 257-259, 2016
"Here, by analysing global demographic data, we show that improvements in survival with age tend to decline after age 100, and that the age at death of the world’s oldest person has not increased since the 1990s. Our results strongly suggest that the maximum lifespan of humans is fixed and subject to natural constraints."
Parkinson's disease protection may begin in the gut MedicalXpress October 5, 2016
"University of Iowa researchers have found that the gut may be key to preventing Parkinson’s disease. Cells located in the intestine spark an immune response that protects nerve cells, or neurons, against damage connected with Parkinson’s disease. Acting like detectives, the immune intestinal cells identify damaged machinery within neurons and discard the defective parts. That action ultimately preserves neurons whose impairment or death is known to cause Parkinson’s. Illustration courtesy of Veena Prahlad."
Genome-wide compendium and functional assessment of in vivo heart enhancers Nature Communications 2016
"Our study provides a comprehensive catalogue of human heart enhancers for use in clinical whole-genome sequencing studies and highlights the importance of enhancers for cardiac function."
Genome-wide compendium and functional assessment of in vivo heart enhancers Nature Communications 2016, 05 October 2016
Roche gets boost from FDA in bid to expand uses for Actemra Reuters Oct 5, 2016
"The U.S. Food and Drug Administration has granted breakthrough status to Roche's rheumatoid arthritis medication Actemra for giant cell arteritis, the Swiss drugmaker said, a step which could help it broaden applications for the medicine"
Smartphone-Based Accurate Analysis of Retinal Vasculature towards Point-of-Care Diagnostics Scientific Reports 04 October 2016
In-vivo Imaging of Magnetic Fields Induced by Transcranial Direct Current Stimulation (tDCS) in Human Brain using MRI Scientific Reports 04 October 2016
Transcranial direct current stimulation (tDCS) is an emerging non-invasive neuromodulation technique that applies mA currents at the scalp to modulate cortical excitability.
Psychotherapy sessions are best in the morning when levels of helpful hormone are high MedicalXpress October 4, 2016
"The findings were reported in the article "Timing matters: Endogenous cortisol mediates benefits from early-day psychotherapy" in the journal Psychoneuroendocrinology."
Complete prevention of blood loss with self-sealing haemostatic needles Nature Materials 03 October 2016
Botox injections get another nod for treating migraine headaches Havard Health Publications July 2016
Could a New Universal Influenza Vaccine Design Spell the End of Winter Flu Season? GEN News Highlights Oct 3, 2016
Increased burden of ultra-rare protein-altering variants among 4,877 individuals with schizophrenia Nature Neuroscience 03 October 2016
Prediabetes Risk in Adult Americans According to a Risk Test JAMA October 03, 2016
Tissue-specific mutation accumulation in human adult stem cells during life Nature 03 October 2016
Mitochondrial Mobility and Neuronal Recovery The England Journal of Medecine September 29, 2016
Hope for patients with hair loss: Arthritis drug spurs regrowth Yale News September 22, 2016
Novel Nanodevice Mimics Human Biological Synapses GEN News Highlights Sep 30, 2016
Expanded use for Novartis’ Periodic Fever Syndrome drug after 3 new FDA approvals European Pharceutical Review 27 September 2016
"Ilaris is the first and only FDA approved biologic treatment for Tumor Necrosis Factor-Receptor Associated Periodic Syndrome (TRAPS), Hyperimmunoglobulin D Syndrome (HIDS)/Mevalonate Kinase Deficiency (MKD) and Familial Mediterranean Fever (FMF)."
Popular Painkillers Like Ibuprofen Are Linked to Heart Problems TIME Sept. 28, 2016
Interventions to prevent and reduce physician burnout: a systematic review and meta-analysis The Lancet 28 September 2016
Why big pharma wants to collect 2 million genomes Nature 28 September 2016
Team suggests nanoscale electronic motion sensor as DNA sequencer Phys Org September 28, 2016
New imaging technique in Alzheimer's disease opens up possibilities for drug development MedicalXpress September 28, 2016
First 'three person baby' born using new method BBC News 27 September 2016
World’s first baby born with novel three-parent embryo technique STAT September 27, 2016
Pinpointing a brain circuit that can keep fears at bay MIT News September 26, 2016
"MIT scientists have identified a way to enhance the long-term benefit of exposure therapy in rats, offering a way to improve the therapy in people suffering from phobias and more complicated conditions such as post-traumatic stress disorder (PTSD)."
A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication Nature Communications 27 September 2016
"An innovative new strategy for lowering refractory high blood pressure? Dr Eric Topol"
Radical protein modifications C&EN September 26, 2016 |Versatile method uses C–C bond formation to decorate proteins with various groups
"The approach, developed by Benjamin G. Davis and coworkers at the University of Oxford, could make it easier to study the structure and biological functions of proteins—especially when combined with other protein-modifying techniques such as site-directed mutagenesis, unnatural amino acid mutagenesis, and bioorthogonal chemistry. It could also lead to new types of protein drugs or “synthetic biologics.”"
Pain kept this young woman from eating for 5 years, and doctors didn’t know why The Washington Post September 26, 2016
New research clarifies how cells take in cholesterol and offers insight on Ebola MedicalXpress September 27, 2016
CRISPR toolbox expanded by protein that cuts RNA in two distinct ways Phys Org September 27, 2016
New Protein Target Offers Hope for Crohn's Sufferers GEN News Highlights Sep 21, 2016
Association of Systolic Blood Pressure Variability With Mortality, Coronary Heart Disease, Stroke, and Renal Disease J Am Coll Cardiol. September 27, 2016
New Approach Tackles Multiple Sclerosis by Targeting Lymph Nodes GEN News Highlights Sep 16, 2016
Abeona enrols 5th patient in gene therapy Epidermolysis Bullosa trial European Pharmaceutical Review 16 September 2016
A Wake-up Call for Type 2 Diabetes? the New England Journal of Medecine September 15, 2016
"This study examines an established association between a variant in a melatonin-receptor gene and type 2 diabetes, yielding insights into how the variant confers susceptibility to the disease."
The Mass Production of Redundant, Misleading, and Conflicted Systematic Reviews and Meta-analyses 2016 Milbank Memorial Fund.
A spark at the periphery Nature Biotechnology 08 September 2016
"Electroceutical devices that stimulate the peripheral nervous system come to the fore. Emily Waltz reports."
"ACROSS study shows that patients with relapsing remitting multiple sclerosis (RRMS) continuously treated with Gilenya® (fingolimod) had significantly lower disability progression compared to those whose treatment was interrupted"
Statins: we need an independent review The bmj 15 September 2016
Asterias stem cell therapy shows promise in spinal cord paralysis: U.S. study Reuters Sep 14, 2016
"An experimental stem cell therapy developed by Asterias Biotherapeutics restored some movement to patients paralyzed by recent spinal cord injuries, according to interim data from a small study being presented on Wednesday."
Espoir pour les patients qui vivent avec des lésions de la moelle épinière Asterias' ongoing AST-OPC1 SCiSTAR Ph1/2a
Mice produced by mitotic reprogramming of sperm injected into haploid parthenogenotes Nature Communications 13 September 2016
"Des chercheurs sont parvenus à reproduire des souris sans recourir à des ovocytes" Le Monde
Scientists Honored for Hep C Research The WSJ Sept. 13, 2016
Three scientists whose work helped transform hepatitis C treatment are among the winners of the 2016 Lasker Awards
Michael J. Sofia, 58 years old, the lead inventor of the drug sofosbuvir (brand-name drug: Sovaldi)
Harnessing adolescent values to motivate healthier eating PNAS July 23, 2016 How to get teenagers to eat healthy?
"Hypertension is nearly universal yet poorly controlled in the elderly despite proven benefits of intensive treatment."
In Vivo Cellular Reprogramming: The Next Generation Cell 8 September 2016
"Here, we review the progress in direct cellular reprogramming, with a focus on the paradigm of in vivo reprogramming for regenerative medicine, while pointing to hurdles that must be overcome to translate this technology into future therapeutics."
Statins or not? New study aims to help doctors and patients decide CNN September 9, 2016
Interpretation of the evidence for the efficacy and safety of statin therapy The Lancet 08 September 2016
ART to Prevent HIV Transmission The New England Journal of Medecine
"An interim analysis showed that early initiation of antiretroviral therapy achieved a 96% reduction in the incidence of HIV-1 infection in serodiscordant couples. Is the protection offered by ART durable in such couples? New research findings are summarized in a short video."
How to Make a Smartphone Detect Anemia MIT Technology Review September 7, 2016
Applications of CRISPR technologies in research and beyond Nature Biotechnology 2016, 933–941
One Hundred Year Study on Artificial Intelligence (AI100) 2016 Report, Stanford September 6, 2016.
Striking Plasticity of CRISPR-Cas9 and Key Role of Non-target DNA, as Revealed by Molecular Simulations ACS Cent. Sci., September 9, 2016
"CRISPR-Cas9 is a transformative genome editing tool. The first biophysical study—based on multi-microsecond atomistic simulations—discloses key mechanistic insights and calls for novel experiments for its full characterization and improvement"
Bold claim of multiple sclerosis gene discovery comes under withering attack STAT September 9, 2016
In Vivo Cellular Reprogramming: The Next Generation Cell Volume 166, Issue 6, p1386–1396, 8 September 2016
Interpretation of the evidence for the efficacy and safety of statin therapy The Lancet Sept 2016
How to Make a Smartphone Detect Anemia MIT Technology Review September 7, 2016
"The sensors and computers in ordinary smartphones are being used for low-cost, portable medical sensing and diagnosis."
High-throughput measurement of single-cell growth rates using serial microfluidic mass sensor arrays Nature Biotechnology Sept. 2016
VTA dopaminergic neurons regulate ethologically relevant sleep–wake behaviors Nature Neuroscience Sept 2016
Purinergic receptors in the carotid body as a new drug target for controlling hypertension Nature Medicine Sept 2016
Scientists discover how 'super enzyme' speeds up DNA repair Phys Org September 5, 2016
Alzheimer’s disease: reviewing the immediate treatment horizon European Pharmaceutical Review 5 September 2016
Treatment for severe eosinophilic asthma—consistent effect of anti-interleukin-5 antibodies? The Lancet 04 September 2016
From Virtual Nurses To Drug Discovery: 90+ Artificial Intelligence Startups In Healthcare CB Insights August 31, 2016
Treatment of Patients with Cirrhosis N Engl J Med Aug 25, 2016
Can Blood Tests Detect Schizophrenia and Other Mental Illnesses? Newsweek Aug 28, 2016
"This new process provides an entirely new pathway for constructing one of the 'cornerstones' of chiral molecules," said researcher Jin-Quan Yu. UPI Sept. 1, 2016
Opinion: Science in the age of selfies PNAS August 23, 2016
Stem-Cell Treatments Become More Available, and Face More Scrutiny The wall Street Journal Aug. 29, 2016
FDA will hold a hearing next month to consider greater oversight as more clinics open in the U.S.
Simple polymer could unlock more effective bone regeneration treatments Phys Org August 29, 2016
Firefighter describes life after historic face transplant: 'I have hope now' CNN August 24, 2016
Brain Mapped at Single-Neuron Level of Resolution GEN News Highlights Aug 22, 2016
Genome-Wide Association Study Reveals Multiple Loci Influencing Normal Human Facial Morphology PLOS Genetics August 25, 2016
La piste du microbiote intestinal pour expliquer le diabète Le Figaro Santé 05/08/2016
Scientists find genetic code for alcoholism Drug Target Review 5 August 2016
Breakthrough in understanding how stem cells become specialized Phys Org August 4, 2016
L'atout secret des Amish contre l'asthme Le Figaro Santé 04/08/2016
Artificial neurons You've got a nerve The Economist August 6, 2016
Researchers find how proteins control gene expression by binding both DNA and RNA MedicalXpress August 4, 2016
Research shows how cells handle big trash pickup Phys Org August 1, 2016
Iron catalysts can modify amino acids, peptides to create new drug candidates Phys Org August 1, 2016
Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing Nature Genetics August 2016 (Progress in genomics of congenital heart disease)
Virtual microfluidics for digital quantification and single-cell sequencing Nature Methods August 2016
À quoi servent les rêves ? Le Figaro Santé 29/07/2016
AbbVie receives FDA approval for new Hepatitis C drug European Pharmaceutical Review 27 July 2016
L'hypnose pour soulager la douleur des grands brûlés Le Figaro Santé 02/07/2016
Coming of age: the artificial pancreas for type 1 diabetes Diabetologia 30 June 2016
L'impact mesuré des polémiques sur les statines Le Figaro Santé 29/06/2016
Study shows link between canned food, exposure to hormone-disrupting chemical BPA MedicalXpress June 30, 2016
Quelle quantité de sucre se cache dans ce que vous mangez ? Le Figaro Santé 29/06/2016
Small doses of anti-HIV drug efavirenz might treat Alzheimer’s Drug Target Review 29 June 2016
New Technique Advances Understanding of How the Brain Works GEN News Highlights Jun 28, 2016
How Blood Testing Technology Got So Hot Fortune June 23, 2016
Rheumatoid arthritis testing market to hit $399.5m by 2022 European Pharceutical Review 22 June 2016
The HIV therapy market Nature Review Drug Chemistry June 17, 2016
Diagnosing a pancreatc condition has gotten a lot easier, thanks to a new iPad app HopkinsMedicine 2015
Study: Molecular motors shape chromosome structure MIT News Office June 10, 2016
"An MIT-led team has developed a model that explains how chromosomes transform from a loosely twisted bundle (left) into two sister chromatids that form the characteristic X shape in preparation for cell division. "
Synthesis and Sulfur Electrophilicity of the Nuphar Thiaspirane Pharmacophore ACS Cent. Sci., June 2016
Modulating the microbiome Drug Target Review 17 June 2016
A powerful new method for finding drug candidates Drug Target Review June 15, 2016
“Our data suggest that the human proteome is much more broadly targetable with small molecules than has been previously appreciated,” said principal investigator Benjamin F. Cravatt, chair of the Department of Chemical Physiology and member of the Dorris Neuroscience Center and Skaggs Institute for Chemical Biology at TSRI. “That opens up new possibilities for developing scientific probes and ultimately drugs.”
Most antidepressants don’t work on kids and teens, study finds STAT June 8, 2016
"The vast majority of antidepressants given to kids and teens are ineffective and potentially dangerous, according to a new study in The Lancet."
"Interpretation - When considering the risk–benefit profile of antidepressants in the acute treatment of major depressive disorder, these drugs do not seem to offer a clear advantage for children and adolescents. Fluoxetine is probably the best option to consider when a pharmacological treatment is indicated."
Cells Tap Nuclear Energy to Drive Urgent DNA Repair GEN News Highlights Jun 6, 2016
"The cell’s everyday energy needs are satisfied by adenosine triphosphate (ATP) molecules from mitochondria. But in extraordinary circumstances, alternative sources of ATP are available. For example, in fast-proliferating cancer cells, ATP can be generated in the cytoplasm."Alternative ATP, however, can serve useful purposes, too." (Vide infra)
"In the presence of pyrophosphate, the pyrophosphatase NUDIX5 can use ADP-ribose to generate nuclear ATP, which is essential for hormone-induced chromatin remodeling, transcriptional regulation, and cell proliferation."
Gilead bets big on Nimbus' fatty liver disease drug Nature Biotechnology 2016
GILEAD se diversifie via l'acquisition de Nimbus Apollo, et de ses actifs dans la NASH
Gilead confronté au défi de l'après-hépatite C Les Echos 30/05/2016
The primate brain is 'pre-adapted' to face potentially any situation Phys Org June 10, 2016
Enel P, Procyk E, Quilodran R, Dominey PF (2016) Reservoir Computing Properties of Neural Dynamics in Prefrontal Cortex. PLoS Comput Biol 12(6): e1004967
From 4 to 12 hours: "With cold storage, the heart is ideally transplanted in under four hours. It has a low tolerance to the cold because it has to function immediately under transplantation. In the OCS, the time window has tripled, leading to an increase in viable donor hearts."
Liens entre microbiote et AVC
Mouse study suggests autism is not just a disease of the brain MedicalXpress June 9, 2016 - published June 9 in Cell
HIV-1 immune evasion—a threat to effective vaccines? Nature Medecine 2016 by Morgane Rolland "Echappement immunitaire du VIH : une menace pour des vaccins efficaces ?"
"A new study of the impact of cytotoxic T lymphocyte (CTL) escape mutations suggests that holes in the host immune repertoire contribute to poor disease outcomes, owing to a gradual deterioration of the host anti-HIV-1 immune response. This should be accounted for in HIV-1 vaccine development strategies"
TMEM230 gene shown to cause Parkinson’s disease Drug Target Review 6 June 2016
"Scientists have discovered a new cause of Parkinson’s disease – mutations in a gene called TMEM230." "This appears to be the third gene definitively linked to confirmed cases of the common movement disorder."
Researchers find key to Parkinson's disease neurodegeneration MedicalXpress June 8, 2016
"The finding has the potential to lead to new therapies that could slow or stop progression of the devastating illness."
Study identifies how altered gut microbiota causes obesity Drug Target Review June 8, 2016
Acetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome Nature June 9, 2016, 534, 213–217
"How the gut microbiome talks to the brain" Eric Topol
FDA approves Allergan's hypertension treatment Reuters Jun 6, 2016
"The therapy, Byvalson, is a fixed-dose combination of two FDA-approved blood pressure lowering agents."
Ask the doctors: How much fruit can I eat and stay within the sugar guidelines? Harvard Health Publications March 1, 2016
People disabled by a stroke showed substantial recovery when adult stem cells were injected into their brains Stanford Medecine June 2, 2016
Genetic origin of multiplesclerosis discovered GEN News Highlights Jun 2, 2016
"Researchers at the University of British Columbia have discovered a rare genetic mutation that causes multiple sclerosis, which should erase doubts that some forms of the neurological disease are inherited."The findings from this study were published recently in Neuron in an article entitled “Nuclear Receptor NR1H3 in Familial Multiple Sclerosis.”
Audacious project plans to create human genomes from scratch STAT June 2, 2016
New target identified for muscular dystrophy drug Target Review 1 June 2016
Heart Attack Recovery Limited by Short Telomeres GEN News Highlights May 31, 2016
Top-down design brings new DNA structures to life Phys Org May 26, 2016
More information: Science science.sciencemag.org/cgi/doi/10.1126/science.aaf4388
Création de l’ADN humain : voici le projet très secret des scientifiques pour créer des Humains Le Courrier du Soir 16/05/2016
Should you be taking daily low-dose aspirin for heart health? CBS News April 11, 2016
Adenovectors for Gene Therapy GEN Dec 21, 2015
De nombreux médicaments en vente libre inefficaces et risqués Figaro 03/12/2015
"Près d'un produit d'automédication sur 2 est jugé «à proscrire» par des experts en pharmacologie associés à une enquête de 60 millions de consommateurs ."